Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

T.r. De Candia, S.H. Lee, J. Yang, B.L. Browning, P. V. Gejman, D. F. Levinson, B. J. Mowry, J.K. Hewitt, M.E. Goddard, M.C. O'Donovan, S.M. Purcell, D. Posthuma, P. M. Visscher, N.R. Wray, M. C. Keller

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European descent (ED [n = 4,990]) schizophrenia case-control genome-wide association study (GWAS) data set available, the Molecular Genetics of Schizophrenia (MGS) data set. We show how a method that uses genomic similarities at measured SNPs to estimate the additive genetic correlation (SNP correlation [SNP-r
Original languageEnglish
Pages (from-to)463-470
JournalAmerican Journal of Human Genetics
Volume93
Issue number3
DOIs
Publication statusPublished - 2013

Bibliographical note

; International Schizophrenia Consortium; Molecular Genetics of Schizophrenia Collaboration

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