@article{7d69958f6daf4d709365d3112682cf0e,
title = "Adenosine A2A receptors control glutamatergic synaptic plasticity in fast spiking interneurons of the prefrontal cortex",
abstract = "Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent behavior such as working memory, reversal learning and effort-based decision making, it is not known whether A2AR control glutamatergic synapse plasticity within the medial PFC (mPFC). To elucidate that, we tested whether A2AR blockade affects long-term plasticity (LTP) of excitatory post-synaptic potentials in pyramidal neurons and fast spiking (FS) interneurons in layer 5 of the mPFC and of population spikes. Our results show that A2AR are enriched at mPFC synapses, where their blockade reversed the direction of plasticity at excitatory synapses onto layer 5 FS interneurons from LTP to long-term depression, while their blockade had no effect on the induction of LTP at excitatory synapses onto layer 5 pyramidal neurons. At the network level, extracellularly induced LTP of population spikes was reduced by A2AR blockade. The interneuron-specificity of A2AR in controlling glutamatergic synapse LTP may ensure that during periods of high synaptic activity, a proper excitation/inhibition balance is maintained within the mPFC.",
keywords = "A receptor, Adenosine, Electrophysiology, Fast-spiking interneurons, LTP and LTD, Prefrontal cortex (PFC), Synaptic plasticity",
author = "Amber Kerkhofs and Canas, {Paula M.} and Timmerman, {A. J.} and Heistek, {Tim S.} and Real, {Joana I.} and Carolina Xavier and Cunha, {Rodrigo A.} and Mansvelder, {Huibert D.} and Ferreira, {Samira G.}",
year = "2018",
month = mar,
day = "20",
doi = "10.3389/fphar.2018.00133",
language = "English",
volume = "9",
pages = "1--12",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media S.A.",
number = "20 March",
}