ADHD in Dutch adults: heritability and linkage study

V. Savyuk, J.J. Hottenga, P.E. Slagboom, M.A. Distel, E.J.C. de Geus, G. Willemsen, D.I. Boomsma

Research output: Contribution to JournalArticle

Abstract

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental phenotype that persists into adulthood. This study investigated the heritability of inattentive and hyperactive symptoms and of total ADHD symptomatology load (ADHD index) in adults and performed linkage scans for these dimensions. Data on sibling pairs and their family members from the Netherlands Twin Register with genotype and phenotype data for inattention, hyperactivity and ADHD index (~750 sib-pairs) were analyzed. Phenotypes were assessed with the short self-report form of the Conners' Adult ADHD Rating Scales (CAARS). Heritabilities were estimated in SOLAR under polygenic models. Genome-wide linkage scans were performed using variance components (VC) in MERLIN and MINX and model-based linkage analysis was carried out in MENDEL with empirical evaluation of the results via simulations. Heritability estimates for inattention, hyperactivity and ADHD index were 35%, 23%, and 31%, respectively. Chromosomes 18q21.31-18q21.32 (VC LOD = 4.58, p
Original languageEnglish
Pages (from-to)352-362
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume156
Issue number3
DOIs
Publication statusPublished - 2011

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