Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms

K.R. Monk, J. Hamann, T. Langenhan, S. Nijmeijer, T. Schoneberg, I. Liebscher

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in humans. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated in recent years, the underlying molecular functions have only recently begun to be elucidated. In this minireview, we present an overview of our current knowledge on aGPCR activation and signal transduction with a focus on the latest findings regarding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on translational approaches that may derive from understanding aGPCR pharmacology.
Original languageEnglish
Pages (from-to)617-623
JournalMolecular Pharmacology
Volume88
Issue number3
DOIs
Publication statusPublished - 2015

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G-Protein-Coupled Receptors
Pharmacology
Signal Transduction
Ligands
In Vitro Techniques

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Monk, K.R. ; Hamann, J. ; Langenhan, T. ; Nijmeijer, S. ; Schoneberg, T. ; Liebscher, I. / Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms. In: Molecular Pharmacology. 2015 ; Vol. 88, No. 3. pp. 617-623.
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Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms. / Monk, K.R.; Hamann, J.; Langenhan, T.; Nijmeijer, S.; Schoneberg, T.; Liebscher, I.

In: Molecular Pharmacology, Vol. 88, No. 3, 2015, p. 617-623.

Research output: Contribution to JournalArticleAcademicpeer-review

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