Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study

S. Vogelezang, C. Monnereau, R. Gaillard, C.M. Renders, A. Hofman, V.W.V. Jaddoe, J.F. Felix

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Genome-wide association studies in adults have identified genetic loci associated with adiposity measures. Little is known about the effects of these loci on growth and body fat distribution from early childhood onwards. Methods: In a population-based prospective cohort study among 4144 children, we examined the associations of weighted risk scores combining 29 known genetic markers of adult body mass index (BMI) and 14 known genetic markers of adult waist-hip ratio (WHR) with peak weight velocity, peak height velocity, age at adiposity peak and BMI at adiposity peak in early infancy and additionally with BMI, total fat mass, android/gynoid fat ratio and preperitoneal fat area at the median age of 6.0 years (95% range 5.7, 7.8). Results: A higher adult BMI genetic risk score was associated with a higher age at adiposity peak in infancy and a higher BMI, total fat mass, android/gynoid fat ratio and preperitoneal fat area in childhood (P=0.05, 1.5 × 10
Original languageEnglish
Pages (from-to)1001-1009
JournalInternational Journal of Obesity
Volume39
Issue number6
DOIs
Publication statusPublished - 2015

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