Advances in hydrophillic interaction liquid chromatography for pharmaceutical analysis

Aurelie Periat, Isabelle Kohler, Davy Guillarme, Jean Luc Veuthey

Research output: Contribution to JournalArticleAcademicpeer-review


Hydrophilic interaction liquid chromatography (HILIC) has recently become more important, particularly for the analysis of polar drugs, metabolites and biologically relevant compounds in glycomics, proteomics, metabolomics and clinical analysis. HILIC makes it possible to increase the retention of polar compounds, achieve orthogonal selectivity and increase mass spectrometry (MS) sensitivity, compared with reversed-phase liquid chromatography. This article discusses the advantages and limitations of HILIC in a variety of practical applications in the pharmaceutical industry.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalLC GC Europe
Issue number5 SUPPL.
Publication statusPublished - 2 May 2013
Externally publishedYes


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