Abstract
The past decades in organic chemistry have witnessed significant improvements in synthetic efficiency as a result of considerable progress in cascade reactions, tandem reactions, and related one-pot processes. These methods are less time-consuming and produce less waste compared to the classical stepwise approach. However, cascade chemistry requires a more careful design and compatible reaction types for success. Palladium-catalyzed cross-coupling reactions, with their well understood multistep catalytic cycles, form a promising basis for the design of cascade reactions. Furthermore, they are compatible with a range of functional groups and can be combined with a range of secondary transformations. The resulting palladium-catalyzed cascade reactions have provided access to a plethora of complex small molecules of high medicinal relevance. This review provides an overview of the developments in palladium-catalyzed cascade reactions since 2011, classified according to the initiation, propagation, and termination steps comprising the palladium cascade reactions. This classification should assist the reader and may provide inspiration for the design of new cascade reactions. (Figure presented.).
| Original language | English |
|---|---|
| Pages (from-to) | 3821-3871 |
| Number of pages | 51 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 360 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 18 Oct 2018 |
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Keywords
- cascade reactions
- catalysis
- cyclization
- domino reactions
- palladium
Cite this
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Advances in Palladium-Catalyzed Cascade Cyclizations. / Biemolt, Jasper; Ruijter, Eelco.
In: Advanced Synthesis and Catalysis, Vol. 360, No. 20, 18.10.2018, p. 3821-3871.Research output: Contribution to Journal › Review article › Academic › peer-review
TY - JOUR
T1 - Advances in Palladium-Catalyzed Cascade Cyclizations
AU - Biemolt, Jasper
AU - Ruijter, Eelco
PY - 2018/10/18
Y1 - 2018/10/18
N2 - The past decades in organic chemistry have witnessed significant improvements in synthetic efficiency as a result of considerable progress in cascade reactions, tandem reactions, and related one-pot processes. These methods are less time-consuming and produce less waste compared to the classical stepwise approach. However, cascade chemistry requires a more careful design and compatible reaction types for success. Palladium-catalyzed cross-coupling reactions, with their well understood multistep catalytic cycles, form a promising basis for the design of cascade reactions. Furthermore, they are compatible with a range of functional groups and can be combined with a range of secondary transformations. The resulting palladium-catalyzed cascade reactions have provided access to a plethora of complex small molecules of high medicinal relevance. This review provides an overview of the developments in palladium-catalyzed cascade reactions since 2011, classified according to the initiation, propagation, and termination steps comprising the palladium cascade reactions. This classification should assist the reader and may provide inspiration for the design of new cascade reactions. (Figure presented.).
AB - The past decades in organic chemistry have witnessed significant improvements in synthetic efficiency as a result of considerable progress in cascade reactions, tandem reactions, and related one-pot processes. These methods are less time-consuming and produce less waste compared to the classical stepwise approach. However, cascade chemistry requires a more careful design and compatible reaction types for success. Palladium-catalyzed cross-coupling reactions, with their well understood multistep catalytic cycles, form a promising basis for the design of cascade reactions. Furthermore, they are compatible with a range of functional groups and can be combined with a range of secondary transformations. The resulting palladium-catalyzed cascade reactions have provided access to a plethora of complex small molecules of high medicinal relevance. This review provides an overview of the developments in palladium-catalyzed cascade reactions since 2011, classified according to the initiation, propagation, and termination steps comprising the palladium cascade reactions. This classification should assist the reader and may provide inspiration for the design of new cascade reactions. (Figure presented.).
KW - cascade reactions
KW - catalysis
KW - cyclization
KW - domino reactions
KW - palladium
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U2 - 10.1002/adsc.201800526
DO - 10.1002/adsc.201800526
M3 - Review article
VL - 360
SP - 3821
EP - 3871
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
SN - 1615-4150
IS - 20
ER -