Affected connectivity organization of the reward system structure in obesity

I. Marqués-Iturria; L. H. Scholtens; M. Garolera; R. Pueyo; I. García-García; P. González-Tartiere; B. Segura; C. Junqué; M. J. Sender-Palacios; M. Vernet-Vernet; C. Sánchez-Garre; M. A. de Reus; M. A. Jurado; M. P. van den Heuvel

doi:10.1016/j.neuroimage.2015.02.012

Affected connectivity organization of the reward system structure in obesity

I. Marqués-Iturria, L. H. Scholtens, M. Garolera, R. Pueyo, I. García-García, P. González-Tartiere, B. Segura, C. Junqué, M. J. Sender-Palacios, M. Vernet-Vernet, C. Sánchez-Garre, M. A. de Reus, M. A. Jurado^*, M. P. van den Heuvel

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

With the prevalence of obesity rapidly increasing worldwide, understanding the processes leading to excessive eating behavior becomes increasingly important. Considering the widely recognized crucial role of reward processes in food intake, we examined the white matter wiring and integrity of the anatomical reward network in obesity. Anatomical wiring of the reward network was reconstructed derived from diffusion weighted imaging in 31 obese participants and 32 normal-weight participants. Network wiring was compared in terms of the white matter volume as well as in terms of white matter microstructure, revealing lower number of streamlines and lower fiber integrity within the reward network in obese subjects. Specifically, the orbitofrontal cortex and striatum nuclei including accumbens, caudate and putamen showed lower strength and network clustering in the obesity group as compared to healthy controls. Our results provide evidence for obesity-related disruptions of global and local anatomical connectivity of the reward circuitry in regions that are key in the reinforcing mechanisms of eating-behavior processes.

Original language	English
Pages (from-to)	100-106
Number of pages	7
Journal	NeuroImage
Volume	111
DOIs	https://doi.org/10.1016/j.neuroimage.2015.02.012
Publication status	Published - 1 May 2015
Externally published	Yes

Funding

The authors thank all the participants who made this study possible. They also thank Encarnació Tor for the performance of blood analyses. This study was supported by grants PSI2013-48045-C2-1-P to María Ángeles Jurado and PSI2013-48045-C2-2-P to Maite Garolera from MINECO , grant ADR2011-2012 from the University of Barcelona to Idoia Marqués-Iturria, and grant 2014 SGR 98 from the Government of Catalonia to Neuropsychology Group.

Keywords

Body mass index
Diffusion imaging
Eating
Neuroanatomy
Orbitofrontal cortex
Striatum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuroimage.2015.02.012

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Marqués-Iturria, I., Scholtens, L. H., Garolera, M., Pueyo, R., García-García, I., González-Tartiere, P., Segura, B., Junqué, C., Sender-Palacios, M. J., Vernet-Vernet, M., Sánchez-Garre, C., de Reus, M. A., Jurado, M. A., & van den Heuvel, M. P. (2015). Affected connectivity organization of the reward system structure in obesity. NeuroImage, 111, 100-106. https://doi.org/10.1016/j.neuroimage.2015.02.012

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abstract = "With the prevalence of obesity rapidly increasing worldwide, understanding the processes leading to excessive eating behavior becomes increasingly important. Considering the widely recognized crucial role of reward processes in food intake, we examined the white matter wiring and integrity of the anatomical reward network in obesity. Anatomical wiring of the reward network was reconstructed derived from diffusion weighted imaging in 31 obese participants and 32 normal-weight participants. Network wiring was compared in terms of the white matter volume as well as in terms of white matter microstructure, revealing lower number of streamlines and lower fiber integrity within the reward network in obese subjects. Specifically, the orbitofrontal cortex and striatum nuclei including accumbens, caudate and putamen showed lower strength and network clustering in the obesity group as compared to healthy controls. Our results provide evidence for obesity-related disruptions of global and local anatomical connectivity of the reward circuitry in regions that are key in the reinforcing mechanisms of eating-behavior processes.",

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Marqués-Iturria, I, Scholtens, LH, Garolera, M, Pueyo, R, García-García, I, González-Tartiere, P, Segura, B, Junqué, C, Sender-Palacios, MJ, Vernet-Vernet, M, Sánchez-Garre, C, de Reus, MA, Jurado, MA & van den Heuvel, MP 2015, 'Affected connectivity organization of the reward system structure in obesity', NeuroImage, vol. 111, pp. 100-106. https://doi.org/10.1016/j.neuroimage.2015.02.012

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AU - Scholtens, L. H.

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AU - García-García, I.

AU - González-Tartiere, P.

AU - Segura, B.

AU - Junqué, C.

AU - Sender-Palacios, M. J.

AU - Vernet-Vernet, M.

AU - Sánchez-Garre, C.

AU - de Reus, M. A.

AU - Jurado, M. A.

AU - van den Heuvel, M. P.

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N2 - With the prevalence of obesity rapidly increasing worldwide, understanding the processes leading to excessive eating behavior becomes increasingly important. Considering the widely recognized crucial role of reward processes in food intake, we examined the white matter wiring and integrity of the anatomical reward network in obesity. Anatomical wiring of the reward network was reconstructed derived from diffusion weighted imaging in 31 obese participants and 32 normal-weight participants. Network wiring was compared in terms of the white matter volume as well as in terms of white matter microstructure, revealing lower number of streamlines and lower fiber integrity within the reward network in obese subjects. Specifically, the orbitofrontal cortex and striatum nuclei including accumbens, caudate and putamen showed lower strength and network clustering in the obesity group as compared to healthy controls. Our results provide evidence for obesity-related disruptions of global and local anatomical connectivity of the reward circuitry in regions that are key in the reinforcing mechanisms of eating-behavior processes.

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Affected connectivity organization of the reward system structure in obesity

Abstract

Funding

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

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