Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD)

S.S. Poil, S. Bollmann, C. Ghisleni, R.L. O'Gorman, P. Klaver, J. Ball, D. Eich-Höchli, D. Brandeis, L. Michels

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: Objective biomarkers for attention-deficit/hyperactivity disorder (ADHD) could improve diagnostics or treatment monitoring of this psychiatric disorder. The resting electroencephalogram (EEG) provides non-invasive spectral markers of brain function and development. Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification. Methods: This study provides an integrated analysis of ADHD and developmental effects in children and adults using regression analysis and support vector machine classification of spectral resting (eyes-closed) EEG biomarkers in order to clarify their diagnostic value. Results: ADHD effects on EEG strongly depend on age and frequency. We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups. However, for ADHD adults we found a slowing in alpha frequency combined with a higher power in alpha-1 (8-10. Hz) and beta (13-30. Hz). Support vector machine classification of ADHD adults versus controls yielded a notable cross validated sensitivity of 67% and specificity of 83% using power and central frequency from all frequency bands. ADHD children were not classified convincingly with these markers. Conclusions: Resting state electrophysiology is altered in ADHD, and these electrophysiological impairments persist into adulthood. Significance: Spectral biomarkers may have both diagnostic and prognostic value. © 2014 International Federation of Clinical Neurophysiology.
Original languageEnglish
Pages (from-to)1504-1506
JournalClinical Neurophysiology
Volume125
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Dive into the research topics of 'Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD)'. Together they form a unique fingerprint.

Cite this