Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

Margherita Malanchini, Emily Smith-Woolley, Ziada Ayorech, Kaili Rimfeld, Eva Krapohl, Eero Vuoksimaa, Tellervo Korhonen, Meike Bartels, Toos C E M van Beijsterveldt, Richard J Rose, Sebastian Lundström, Henrik Anckarsäter, Jaakko Kaprio, Paul Lichtenstein, Dorret I Boomsma, Robert Plomin

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.

METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.

RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.

CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

LanguageEnglish
Pages1-9
Number of pages9
JournalPsychological Medicine
DOIs
StateE-pub ahead of print - 11 Jun 2018

Fingerprint

Smoking
Aggression
Mothers
Pregnancy
Twin Studies
Adolescent Behavior
Maternal Age
Parenting
Pregnancy Outcome
Sweden
Netherlands
Meta-Analysis
Demography
Education

Cite this

Malanchini, Margherita ; Smith-Woolley, Emily ; Ayorech, Ziada ; Rimfeld, Kaili ; Krapohl, Eva ; Vuoksimaa, Eero ; Korhonen, Tellervo ; Bartels, Meike ; van Beijsterveldt, Toos C E M ; Rose, Richard J ; Lundström, Sebastian ; Anckarsäter, Henrik ; Kaprio, Jaakko ; Lichtenstein, Paul ; Boomsma, Dorret I ; Plomin, Robert. / Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. In: Psychological Medicine. 2018 ; pp. 1-9
@article{d05ccd75a2bd47ca893f9f0520de098f,
title = "Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium",
abstract = "BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4{\%} (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1{\%} of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.",
author = "Margherita Malanchini and Emily Smith-Woolley and Ziada Ayorech and Kaili Rimfeld and Eva Krapohl and Eero Vuoksimaa and Tellervo Korhonen and Meike Bartels and {van Beijsterveldt}, {Toos C E M} and Rose, {Richard J} and Sebastian Lundstr{\"o}m and Henrik Anckars{\"a}ter and Jaakko Kaprio and Paul Lichtenstein and Boomsma, {Dorret I} and Robert Plomin",
year = "2018",
month = "6",
day = "11",
doi = "10.1017/S0033291718001344",
language = "English",
pages = "1--9",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

Malanchini, M, Smith-Woolley, E, Ayorech, Z, Rimfeld, K, Krapohl, E, Vuoksimaa, E, Korhonen, T, Bartels, M, van Beijsterveldt, TCEM, Rose, RJ, Lundström, S, Anckarsäter, H, Kaprio, J, Lichtenstein, P, Boomsma, DI & Plomin, R 2018, 'Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium' Psychological Medicine, pp. 1-9. DOI: 10.1017/S0033291718001344

Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. / Malanchini, Margherita; Smith-Woolley, Emily; Ayorech, Ziada; Rimfeld, Kaili; Krapohl, Eva; Vuoksimaa, Eero; Korhonen, Tellervo; Bartels, Meike; van Beijsterveldt, Toos C E M; Rose, Richard J; Lundström, Sebastian; Anckarsäter, Henrik; Kaprio, Jaakko; Lichtenstein, Paul; Boomsma, Dorret I; Plomin, Robert.

In: Psychological Medicine, 11.06.2018, p. 1-9.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Aggressive behaviour in childhood and adolescence

T2 - Psychological Medicine

AU - Malanchini,Margherita

AU - Smith-Woolley,Emily

AU - Ayorech,Ziada

AU - Rimfeld,Kaili

AU - Krapohl,Eva

AU - Vuoksimaa,Eero

AU - Korhonen,Tellervo

AU - Bartels,Meike

AU - van Beijsterveldt,Toos C E M

AU - Rose,Richard J

AU - Lundström,Sebastian

AU - Anckarsäter,Henrik

AU - Kaprio,Jaakko

AU - Lichtenstein,Paul

AU - Boomsma,Dorret I

AU - Plomin,Robert

PY - 2018/6/11

Y1 - 2018/6/11

N2 - BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

AB - BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

U2 - 10.1017/S0033291718001344

DO - 10.1017/S0033291718001344

M3 - Article

SP - 1

EP - 9

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -