Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

Margherita Malanchini, Emily Smith-Woolley, Ziada Ayorech, Kaili Rimfeld, Eva Krapohl, Eero Vuoksimaa, Tellervo Korhonen, Meike Bartels, Toos C E M van Beijsterveldt, Richard J Rose, Sebastian Lundström, Henrik Anckarsäter, Jaakko Kaprio, Paul Lichtenstein, Dorret I Boomsma, Robert Plomin

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.

METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.

RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.

CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

Original languageEnglish
Pages (from-to)646-654
Number of pages9
JournalPsychological Medicine
Volume49
Issue number4
DOIs
Publication statusPublished - Mar 2019

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Smoking
Aggression
Mothers
Pregnancy
Twin Studies
Adolescent Behavior
Maternal Age
Parenting
Pregnancy Outcome
Sweden
Netherlands
Meta-Analysis
Demography
Education

Cite this

Malanchini, Margherita ; Smith-Woolley, Emily ; Ayorech, Ziada ; Rimfeld, Kaili ; Krapohl, Eva ; Vuoksimaa, Eero ; Korhonen, Tellervo ; Bartels, Meike ; van Beijsterveldt, Toos C E M ; Rose, Richard J ; Lundström, Sebastian ; Anckarsäter, Henrik ; Kaprio, Jaakko ; Lichtenstein, Paul ; Boomsma, Dorret I ; Plomin, Robert. / Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. In: Psychological Medicine. 2019 ; Vol. 49, No. 4. pp. 646-654.
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title = "Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium",
abstract = "BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4{\%} (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1{\%} of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.",
author = "Margherita Malanchini and Emily Smith-Woolley and Ziada Ayorech and Kaili Rimfeld and Eva Krapohl and Eero Vuoksimaa and Tellervo Korhonen and Meike Bartels and {van Beijsterveldt}, {Toos C E M} and Rose, {Richard J} and Sebastian Lundstr{\"o}m and Henrik Anckars{\"a}ter and Jaakko Kaprio and Paul Lichtenstein and Boomsma, {Dorret I} and Robert Plomin",
year = "2019",
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Malanchini, M, Smith-Woolley, E, Ayorech, Z, Rimfeld, K, Krapohl, E, Vuoksimaa, E, Korhonen, T, Bartels, M, van Beijsterveldt, TCEM, Rose, RJ, Lundström, S, Anckarsäter, H, Kaprio, J, Lichtenstein, P, Boomsma, DI & Plomin, R 2019, 'Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium' Psychological Medicine, vol. 49, no. 4, pp. 646-654. https://doi.org/10.1017/S0033291718001344

Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. / Malanchini, Margherita; Smith-Woolley, Emily; Ayorech, Ziada; Rimfeld, Kaili; Krapohl, Eva; Vuoksimaa, Eero; Korhonen, Tellervo; Bartels, Meike; van Beijsterveldt, Toos C E M; Rose, Richard J; Lundström, Sebastian; Anckarsäter, Henrik; Kaprio, Jaakko; Lichtenstein, Paul; Boomsma, Dorret I; Plomin, Robert.

In: Psychological Medicine, Vol. 49, No. 4, 03.2019, p. 646-654.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Aggressive behaviour in childhood and adolescence

T2 - the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

AU - Malanchini, Margherita

AU - Smith-Woolley, Emily

AU - Ayorech, Ziada

AU - Rimfeld, Kaili

AU - Krapohl, Eva

AU - Vuoksimaa, Eero

AU - Korhonen, Tellervo

AU - Bartels, Meike

AU - van Beijsterveldt, Toos C E M

AU - Rose, Richard J

AU - Lundström, Sebastian

AU - Anckarsäter, Henrik

AU - Kaprio, Jaakko

AU - Lichtenstein, Paul

AU - Boomsma, Dorret I

AU - Plomin, Robert

PY - 2019/3

Y1 - 2019/3

N2 - BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

AB - BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18.RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.

U2 - 10.1017/S0033291718001344

DO - 10.1017/S0033291718001344

M3 - Article

VL - 49

SP - 646

EP - 654

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 4

ER -