Agonist-independent regulation of constitutively active G-protein-coupled receptors.

R. Leurs, M.J. Smit, A.E. Alewijnse, H. Timmerman

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    G-protein-coupled receptors constitute one of the largest protein superfamilies in mammals. Since the cloning of the encoding genes, these important drug targets have been subjected to thorough biochemical and pharmacological studies. It has become clear that G-protein-coupled receptors not only transmit signals after stimulation by agonists but can also spontaneously couple to signal-transduction pathways. Recent findings show that constitutively active G-protein-coupled receptors can also be regulated in an agonist-independent manner, which has important implications for the interpretation of the actions of (inverse) agonists and the results of site-directed-mutagenesis studies. Copyright (C) 1998 Elsevier Science Ltd.
    Original languageEnglish
    Pages (from-to)418-422
    JournalTrends in Biochemical Sciences
    Volume23
    DOIs
    Publication statusPublished - 1998

    Fingerprint

    Dive into the research topics of 'Agonist-independent regulation of constitutively active G-protein-coupled receptors.'. Together they form a unique fingerprint.

    Cite this