Alpha-Ketoglutarate dietary supplementation to improve health in humans

Bibek Gyanwali; Zi Xiang Lim; Janjira Soh; Clarissa Lim; Shou Ping Guan; Jorming Goh; Andrea B. Maier; Brian K. Kennedy

doi:10.1016/j.tem.2021.11.003

Alpha-Ketoglutarate dietary supplementation to improve health in humans

Bibek Gyanwali
, Zi Xiang Lim
, Janjira Soh
, Clarissa Lim
, Shou Ping Guan
, Jorming Goh
, Andrea B. Maier
, Brian K. Kennedy^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few studies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans. This review will discuss the regulatory role of AKG in aging, as well as its potential therapeutic use in humans to treat age-related diseases.

Original language	English
Pages (from-to)	136-146
Number of pages	11
Journal	Trends in Endocrinology and Metabolism
Volume	33
Issue number	2
Early online date	21 Dec 2021
DOIs	https://doi.org/10.1016/j.tem.2021.11.003
Publication status	Published - Feb 2022

Bibliographical note

Funding Information:
This work was supported by the National University of Singapore (Start-up Grant DPRT , R183000413133 , and Interventions for Healthy Longevity Grant, R-171-000-083-750 ) and the National University Health System, Centre for Healthy Longevity Grant ( SPOT20AHS3O ).

Publisher Copyright:
© 2021 Elsevier Ltd

Funding

This work was supported by the National University of Singapore (Start-up Grant DPRT , R183000413133 , and Interventions for Healthy Longevity Grant, R-171-000-083-750 ) and the National University Health System, Centre for Healthy Longevity Grant ( SPOT20AHS3O ).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antioxidant
cellular respiration
citric acid cycle
healthspan
ketoglutaric acids
supplement

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10.1016/j.tem.2021.11.003

AlphaKetoglutarate dietary supplementation to improve health in humansFinal published version, 1.38 MBLicence: Article 25fa Dutch Copyright Act

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Cite this

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title = "Alpha-Ketoglutarate dietary supplementation to improve health in humans",

abstract = "Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few studies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans. This review will discuss the regulatory role of AKG in aging, as well as its potential therapeutic use in humans to treat age-related diseases.",

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note = "Funding Information: This work was supported by the National University of Singapore (Start-up Grant DPRT , R183000413133 , and Interventions for Healthy Longevity Grant, R-171-000-083-750 ) and the National University Health System, Centre for Healthy Longevity Grant ( SPOT20AHS3O ). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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AU - Gyanwali, Bibek

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AU - Guan, Shou Ping

AU - Goh, Jorming

AU - Maier, Andrea B.

AU - Kennedy, Brian K.

N1 - Funding Information: This work was supported by the National University of Singapore (Start-up Grant DPRT , R183000413133 , and Interventions for Healthy Longevity Grant, R-171-000-083-750 ) and the National University Health System, Centre for Healthy Longevity Grant ( SPOT20AHS3O ). Publisher Copyright: © 2021 Elsevier Ltd

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AB - Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in worms and mice support this concept. A few studies published in the 1980s and 1990s in humans suggested the potential benefits of AKG in muscle growth, wound healing, and in promoting faster recovery after surgery. So far there are no recently published studies demonstrating the role of AKG in treating aging and age-related diseases; hence, further clinical studies are required to better understand the role of AKG in humans. This review will discuss the regulatory role of AKG in aging, as well as its potential therapeutic use in humans to treat age-related diseases.

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DO - 10.1016/j.tem.2021.11.003

M3 - Review article

AN - SCOPUS:85121794868

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EP - 146

JO - Trends in Endocrinology and Metabolism

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Alpha-Ketoglutarate dietary supplementation to improve health in humans

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Persistent URL (handle)

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