Alterations in the Ventral Attention Network During the Stop-Signal Task in Children With ADHD: An Event-Related Potential Source Imaging Study

Tieme W.P. Janssen, Dirk J. Heslenfeld, Rosa van Mourik, Katleen Geladé, Athanasios Maras, Jaap Oosterlaan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: Deficits in response inhibition figure prominently in models of ADHD; however, attentional deficiencies may better explain previous findings of impaired response inhibition in ADHD. We tested this hypothesis at the neurophysiological level. Method: Dense array ERPs (event-related potentials) were obtained for 46 children with ADHD and 51 controls using the stop-signal task (SST). Early and late components were compared between groups. N2 and P3 components were localized with LAURA distributed linear inverse solution. Results: A success-related N1 modulation was only apparent in the ADHD group. N2 and P3 amplitudes were reduced in ADHD. During the successful inhibition N2, the ADHD group showed reduced activation in right inferior frontal gyrus (rIFG), supplementary motor area (SMA), and right temporoparietal junction (rTPJ), and during failed inhibition in the rIFG. During the successful inhibition P3, reduced activation was found in anterior cingulate cortex (ACC) and SMA. Conclusion: Impairments in the ventral attention network contribute to the psychopathology of ADHD and challenge the dominant view that ADHD is underpinned by impaired inhibitory control.

Original languageEnglish
Pages (from-to)639-650
Number of pages12
JournalJournal of Attention Disorders
Volume22
Issue number7
Early online date20 Apr 2015
DOIs
Publication statusPublished - 1 May 2018

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Evoked Potentials
Motor Cortex
Prefrontal Cortex
Gyrus Cinguli
Psychopathology
Inhibition (Psychology)

Keywords

  • ADHD
  • children
  • electroencephalography
  • inhibition
  • neuroimaging
  • psychopathology

Cite this

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title = "Alterations in the Ventral Attention Network During the Stop-Signal Task in Children With ADHD: An Event-Related Potential Source Imaging Study",
abstract = "Objective: Deficits in response inhibition figure prominently in models of ADHD; however, attentional deficiencies may better explain previous findings of impaired response inhibition in ADHD. We tested this hypothesis at the neurophysiological level. Method: Dense array ERPs (event-related potentials) were obtained for 46 children with ADHD and 51 controls using the stop-signal task (SST). Early and late components were compared between groups. N2 and P3 components were localized with LAURA distributed linear inverse solution. Results: A success-related N1 modulation was only apparent in the ADHD group. N2 and P3 amplitudes were reduced in ADHD. During the successful inhibition N2, the ADHD group showed reduced activation in right inferior frontal gyrus (rIFG), supplementary motor area (SMA), and right temporoparietal junction (rTPJ), and during failed inhibition in the rIFG. During the successful inhibition P3, reduced activation was found in anterior cingulate cortex (ACC) and SMA. Conclusion: Impairments in the ventral attention network contribute to the psychopathology of ADHD and challenge the dominant view that ADHD is underpinned by impaired inhibitory control.",
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Alterations in the Ventral Attention Network During the Stop-Signal Task in Children With ADHD : An Event-Related Potential Source Imaging Study. / Janssen, Tieme W.P.; Heslenfeld, Dirk J.; van Mourik, Rosa; Geladé, Katleen; Maras, Athanasios; Oosterlaan, Jaap.

In: Journal of Attention Disorders, Vol. 22, No. 7, 01.05.2018, p. 639-650.

Research output: Contribution to JournalArticleAcademicpeer-review

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