Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome

I. Koubiyr; T.A.A. Broeders; M. Deloire; B. Brochet; T. Tourdias; J.J.G. Geurts; M.M. Schoonheim; A. Ruet

doi:10.1177/13524585221101470

Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome

I. Koubiyr, T.A.A. Broeders, M. Deloire, B. Brochet, T. Tourdias, J.J.G. Geurts, M.M. Schoonheim, A. Ruet

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

.Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.

Original language	English
Pages (from-to)	1973-1982
Number of pages	10
Journal	Multiple Sclerosis Journal
Volume	28
Issue number	12
Early online date	23 Jun 2022
DOIs	https://doi.org/10.1177/13524585221101470
Publication status	Published - Oct 2022

Bibliographical note

Publisher copyright:
© The Author(s), 2022

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by a grant from the Bordeaux University Hospital. This work has been performed with the help of the French Observatoire of Multiple Sclerosis (OFSEP), which is supported by a grant provided by the French State and handled by the ‘Agence Nationale de la Recherche’, within the framework of the ‘Investments for the Future’ programme, under the reference no. ANR-10-COHO-002.

Funders	Funder number
Bordeaux University Hospital
Agence Nationale de la Recherche	ANR-10-COHO-002

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title = "Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome",

abstract = ".Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.",

author = "I. Koubiyr and T.A.A. Broeders and M. Deloire and B. Brochet and T. Tourdias and J.J.G. Geurts and M.M. Schoonheim and A. Ruet",

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T1 - Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome

AU - Koubiyr, I.

AU - Broeders, T.A.A.

AU - Deloire, M.

AU - Brochet, B.

AU - Tourdias, T.

AU - Geurts, J.J.G.

AU - Schoonheim, M.M.

AU - Ruet, A.

PY - 2022/10

Y1 - 2022/10

N2 - .Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.

AB - .Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.

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Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome

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