Abstract
Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from fatty acid-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.
Original language | English |
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Article number | e13430 |
Pages (from-to) | e13430 |
Journal | Acta Physiologica |
Volume | 228 |
Issue number | 3 |
Early online date | 16 Dec 2019 |
DOIs | |
Publication status | Published - Mar 2020 |
Bibliographical note
© 2019 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.Funding
This publication is based upon work from COST Action CA15203 MITOEAGLE, supported by COST (European Cooperation in Science and Technology). Web site: www.cost.eu . EL was supported by Latvian Council of Science grant project no. lzp‐2018/1‐0082. KT, MP, TK were supported by the institutional research funding IUT23‐1 of the Estonian Ministry of Education and Research.
Funders | Funder number |
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European Cooperation in Science and Technology | CA15203 |
Haridus- ja Teadusministeerium | |
Latvijas Zinātnes Padome | lzp‐2018/1‐0082 |
Keywords
- diabetes
- heart
- lipotoxicity
- mitochondria