Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women

M.J. Delmonico, T.B. Harris, J.S. Lee, M. Visser, M. Nevitt, S.B. Kritchevsky, F.A. Tylavsky, A.B. Newman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

OBJECTIVES: To compare two methods for classifying an individual as sarcopenic for predicting decline in physical function in the Health, Aging and Body Composition Study. DESIGN: Observational cohort study with 5 years of follow-up. SETTING: Communities in Memphis, Tennessee, and Pittsburgh, Pennsylvania. PARTICIPANTS: Men and women aged 70 to 79 (N=2,976, 52% women, 41% black). MEASUREMENTS: Appendicular lean mass (aLM) was measured using dual energy x-ray absorptiometry, and participants were classified as sarcopenic first using aLM divided by height squared and then using aLM adjusted for height and body fat mass (residuals). Incidence of persistent lower extremity limitation (PLL) was measured according to self-report, and change in objective lower extremity performance (LEP) measures were observed using the Short Physical Performance Battery. RESULTS: There was a greater risk of incident PLL in women who were sarcopenic using the residuals sarcopenia method than in women who were not sarcopenic (hazard ratio (HR)=1.34, 95% confidence interval (CI)=1.11-1.61) but not in men. Those defined as sarcopenic using the aLM/ht
Original languageEnglish
Pages (from-to)769-774
JournalJournal of the American Geriatrics Society
Volume55
DOIs
Publication statusPublished - 2007

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