Abstract
Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that behavioral response to peripheral stimuli does not lead to chronic pain. We have investigated the effects of recombinant adeno-associated viral (rAAV)-mediated over-expression of brain-derived neurotrophic factor (BDNF) in the spinal cord on chronic neuropathic pain after unilateral chronic constriction injury (CCI) of the sciatic nerve. The rAAV-BDNF vector was injected into the dorsal horn at the thirteenth thoracic spinal cord vertebra (L
Original language | English |
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Pages (from-to) | 1387-1395 |
Number of pages | 9 |
Journal | Gene Therapy |
Volume | 9 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2002 |