Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

M.J. Eaton, B. Blits, M.J. Ruitenberg, J. Verhaagen, M. Oudega

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that behavioral response to peripheral stimuli does not lead to chronic pain. We have investigated the effects of recombinant adeno-associated viral (rAAV)-mediated over-expression of brain-derived neurotrophic factor (BDNF) in the spinal cord on chronic neuropathic pain after unilateral chronic constriction injury (CCI) of the sciatic nerve. The rAAV-BDNF vector was injected into the dorsal horn at the thirteenth thoracic spinal cord vertebra (L
Original languageEnglish
Pages (from-to)1387-1395
Number of pages9
JournalGene Therapy
Volume9
Issue number20
DOIs
Publication statusPublished - 2002

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