Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

M.J. Eaton; B. Blits; M.J. Ruitenberg; J. Verhaagen; M. Oudega

doi:10.1038/sj.gt.3301814

Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

M.J. Eaton
, B. Blits
, M.J. Ruitenberg
, J. Verhaagen
, M. Oudega

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that behavioral response to peripheral stimuli does not lead to chronic pain. We have investigated the effects of recombinant adeno-associated viral (rAAV)-mediated over-expression of brain-derived neurotrophic factor (BDNF) in the spinal cord on chronic neuropathic pain after unilateral chronic constriction injury (CCI) of the sciatic nerve. The rAAV-BDNF vector was injected into the dorsal horn at the thirteenth thoracic spinal cord vertebra (L

Original language	English
Pages (from-to)	1387-1395
Number of pages	9
Journal	Gene Therapy
Volume	9
Issue number	20
DOIs	https://doi.org/10.1038/sj.gt.3301814
Publication status	Published - 2002

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SDG 3 Good Health and Well-being

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10.1038/sj.gt.3301814

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AU - Verhaagen, J.

AU - Oudega, M.

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Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

Abstract

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