Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Yan Ping Zhu; Sergey Sergeyev; Philippe Franck; Romano V.A. Orru; Bert U.W. Maes

doi:10.1021/acs.orglett.6b02247

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Yan Ping Zhu, Sergey Sergeyev, Philippe Franck, Romano V.A. Orru, Bert U.W. Maes^*

^*Corresponding author for this work

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

Original language	English
Pages (from-to)	4602-4605
Number of pages	4
Journal	Organic letters
Volume	18
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.6b02247
Publication status	Published - 16 Sept 2016

Access to Document

10.1021/acs.orglett.6b02247

Persistent URL (handle)

Persistent link

Cite this

@article{8838c86cd75844c0872ce673e47b137f,

title = "Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids",

abstract = "A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.",

author = "Zhu, {Yan Ping} and Sergey Sergeyev and Philippe Franck and Orru, {Romano V.A.} and Maes, {Bert U.W.}",

year = "2016",

month = sep,

day = "16",

doi = "10.1021/acs.orglett.6b02247",

language = "English",

volume = "18",

pages = "4602--4605",

journal = "Organic letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Amine Activation

T2 - Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

AU - Zhu, Yan Ping

AU - Sergeyev, Sergey

AU - Franck, Philippe

AU - Orru, Romano V.A.

AU - Maes, Bert U.W.

PY - 2016/9/16

Y1 - 2016/9/16

N2 - A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

AB - A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

UR - http://www.scopus.com/inward/record.url?scp=84988603369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988603369&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.6b02247

DO - 10.1021/acs.orglett.6b02247

M3 - Article

AN - SCOPUS:84988603369

SN - 1523-7060

VL - 18

SP - 4602

EP - 4605

JO - Organic letters

JF - Organic letters

IS - 18

ER -

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Abstract

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this