Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Yan Ping Zhu, Sergey Sergeyev, Philippe Franck, Romano V.A. Orru, Bert U.W. Maes*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

Original languageEnglish
Pages (from-to)4602-4605
Number of pages4
JournalOrganic letters
Volume18
Issue number18
DOIs
Publication statusPublished - 16 Sep 2016

Fingerprint

Dive into the research topics of 'Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids'. Together they form a unique fingerprint.

Cite this