Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Yan Ping Zhu; Sergey Sergeyev; Philippe Franck; Romano V.A. Orru; Bert U.W. Maes

doi:10.1021/acs.orglett.6b02247

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Yan Ping Zhu
, Sergey Sergeyev
, Philippe Franck
, Romano V.A. Orru
, Bert U.W. Maes^*

^*Corresponding author for this work

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

Original language	English
Pages (from-to)	4602-4605
Number of pages	4
Journal	Organic letters
Volume	18
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.6b02247
Publication status	Published - 16 Sept 2016

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title = "Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids",

abstract = "A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.",

author = "Zhu, \{Yan Ping\} and Sergey Sergeyev and Philippe Franck and Orru, \{Romano V.A.\} and Maes, \{Bert U.W.\}",

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doi = "10.1021/acs.orglett.6b02247",

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T2 - Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

AU - Zhu, Yan Ping

AU - Sergeyev, Sergey

AU - Franck, Philippe

AU - Orru, Romano V.A.

AU - Maes, Bert U.W.

PY - 2016/9/16

Y1 - 2016/9/16

N2 - A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

AB - A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.

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Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Abstract

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