An adaptive network model of the role of the microbiome-gut-brain axis in insomnia

Sulagna Banerjee, Claudia Chitty, Quinn Lee, Jan Treur*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This paper presents an adaptive network model simulating the role of the gut microbiome for triggering biological mechanisms that alter the circadian cycle, mood and insomnia via the microbiome-gut-brain axis. Simulation graphs provide insight into how these immune and endocrine pathways interact with each other when the levels of the probiotics, Lactobacillus and Bifidobacteria, and pathogenic bacteria were altered. Varying these factors in simulations produced different outcomes for insomnia and sleep deprivation.

Original languageEnglish
Pages (from-to)106-121
Number of pages16
JournalCognitive Systems Research
Volume78
Early online date8 Dec 2022
DOIs
Publication statusPublished - Mar 2023

Bibliographical note

Publisher Copyright:
© 2022

Keywords

  • Adaptive network model
  • Gut-Brain axis
  • Insomnia
  • Microbiome
  • Self- modelling network

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