TY - JOUR
T1 - An adaptive network model of the role of the microbiome-gut-brain axis in insomnia
AU - Banerjee, Sulagna
AU - Chitty, Claudia
AU - Lee, Quinn
AU - Treur, Jan
N1 - Publisher Copyright:
© 2022
PY - 2023/3
Y1 - 2023/3
N2 - This paper presents an adaptive network model simulating the role of the gut microbiome for triggering biological mechanisms that alter the circadian cycle, mood and insomnia via the microbiome-gut-brain axis. Simulation graphs provide insight into how these immune and endocrine pathways interact with each other when the levels of the probiotics, Lactobacillus and Bifidobacteria, and pathogenic bacteria were altered. Varying these factors in simulations produced different outcomes for insomnia and sleep deprivation.
AB - This paper presents an adaptive network model simulating the role of the gut microbiome for triggering biological mechanisms that alter the circadian cycle, mood and insomnia via the microbiome-gut-brain axis. Simulation graphs provide insight into how these immune and endocrine pathways interact with each other when the levels of the probiotics, Lactobacillus and Bifidobacteria, and pathogenic bacteria were altered. Varying these factors in simulations produced different outcomes for insomnia and sleep deprivation.
KW - Adaptive network model
KW - Gut-Brain axis
KW - Insomnia
KW - Microbiome
KW - Self- modelling network
UR - http://www.scopus.com/inward/record.url?scp=85144373194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144373194&partnerID=8YFLogxK
U2 - 10.1016/j.cogsys.2022.12.002
DO - 10.1016/j.cogsys.2022.12.002
M3 - Article
AN - SCOPUS:85144373194
SN - 1389-0417
VL - 78
SP - 106
EP - 121
JO - Cognitive Systems Research
JF - Cognitive Systems Research
ER -