An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

E. Gelens; L. Smeets; L.A. Sliedregt; B.J. van Steen; C.G. Kruse; R. Leurs; R.V.A. Orru

doi:10.1016/j.tetlet.2005.03.146

An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

E. Gelens, L. Smeets, L.A. Sliedregt, B.J. van Steen, C.G. Kruse, R. Leurs, R.V.A. Orru

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3751-3754
Journal	Tetrahedron Letters
Volume	46
Issue number	21
DOIs	https://doi.org/10.1016/j.tetlet.2005.03.146
Publication status	Published - 2005

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10.1016/j.tetlet.2005.03.146

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title = "An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves",

abstract = "An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

author = "E. Gelens and L. Smeets and L.A. Sliedregt and {van Steen}, B.J. and C.G. Kruse and R. Leurs and R.V.A. Orru",

year = "2005",

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T1 - An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

AU - Gelens, E.

AU - Smeets, L.

AU - Sliedregt, L.A.

AU - van Steen, B.J.

AU - Kruse, C.G.

AU - Leurs, R.

AU - Orru, R.V.A.

PY - 2005

Y1 - 2005

N2 - An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. © 2005 Elsevier Ltd. All rights reserved.

AB - An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. © 2005 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2005.03.146

DO - 10.1016/j.tetlet.2005.03.146

M3 - Article

SN - 0040-4039

VL - 46

SP - 3751

EP - 3754

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

Abstract

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