An exploratory study on the association between serotonin and sleep breathing disorders

Mieszko Wieckiewicz*, Helena Martynowicz, Gilles Lavigne, Frank Lobbezoo, Takafumi Kato, Efraim Winocur, Joanna Wezgowiec, Dariusz Danel, Anna Wojakowska, Grzegorz Mazur, Joanna Smardz

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio–video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea–hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels. Clinical Trial Registration : www.ClinicalTrials.gov

Original languageEnglish
Article number11800
Pages (from-to)1-9
Number of pages9
JournalScientific Reports
Volume13
DOIs
Publication statusPublished - 21 Jul 2023

Bibliographical note

Funding Information:
The study was financed by Wroclaw Medical University (grant number SUBK.B160.23.059).

Funding Information:
The authors acknowledge Prof. Jolanta Saczko and Prof. Julita Kulbacka for allowing them to carry out tests in the laboratory of the Department of Molecular and Cellular Biology, Wroclaw Medical University, Poland.

Publisher Copyright:
© 2023, The Author(s).

Funding

The study was financed by Wroclaw Medical University (grant number SUBK.B160.23.059). The authors acknowledge Prof. Jolanta Saczko and Prof. Julita Kulbacka for allowing them to carry out tests in the laboratory of the Department of Molecular and Cellular Biology, Wroclaw Medical University, Poland.

FundersFunder number
Department of Molecular and Cellular Biology
Uniwersytet Medyczny im. Piastów Slaskich we WroclawiuSUBK.B160.23.059
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu

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