Abstract
This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio–video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea–hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels. Clinical Trial Registration : www.ClinicalTrials.gov
Original language | English |
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Article number | 11800 |
Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Scientific Reports |
Volume | 13 |
DOIs | |
Publication status | Published - 21 Jul 2023 |
Bibliographical note
Funding Information:The study was financed by Wroclaw Medical University (grant number SUBK.B160.23.059).
Funding Information:
The authors acknowledge Prof. Jolanta Saczko and Prof. Julita Kulbacka for allowing them to carry out tests in the laboratory of the Department of Molecular and Cellular Biology, Wroclaw Medical University, Poland.
Publisher Copyright:
© 2023, The Author(s).
Funding
The study was financed by Wroclaw Medical University (grant number SUBK.B160.23.059). The authors acknowledge Prof. Jolanta Saczko and Prof. Julita Kulbacka for allowing them to carry out tests in the laboratory of the Department of Molecular and Cellular Biology, Wroclaw Medical University, Poland.
Funders | Funder number |
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Department of Molecular and Cellular Biology | |
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu | SUBK.B160.23.059 |
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu |