An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Dorret I Boomsma, Quinta Helmer, Harold A Nieuwboer, Jouke Jan Hottenga, Marleen H de Moor, Stéphanie M van den Berg, Gareth E Davies, Jacqueline M Vink, Maarten J Schouten, Conor V Dolan, Gonneke Willemsen, Meike Bartels, C.E.M. van Beijsterveldt, Lannie Ligthart, Eco J de Geus

Research output: Scientific - peer-reviewArticle

Abstract

For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores. We analyzed these data in the Mendel software package (Lange et al., Bioinformatics 29(12):1568-1570, 2013) to estimate the contributions of additive and non-additive genetic factors. In contrast to much of the earlier work based on twin data rather than on extended pedigrees, we could also estimate the contribution of shared household effects in the presence of non-additive genetic factors. The estimated broad-sense heritability of neuroticism was 47%, with almost equal contributions of additive and non-additive (dominance) genetic factors. A shared household effect explained 13% and unique environmental factors explained the remaining 40% of the variance in neuroticism.

Original languageEnglish
Pages (from-to)1-11
JournalBehavior Genetics
Volume48
Issue number1
DOIs
StatePublished - 1 Jan 2018

Cite this

Boomsma, Dorret I; Helmer, Quinta; Nieuwboer, Harold A; Hottenga, Jouke Jan; de Moor, Marleen H; van den Berg, Stéphanie M; Davies, Gareth E; Vink, Jacqueline M; Schouten, Maarten J; Dolan, Conor V; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, C.E.M.; Ligthart, Lannie; de Geus, Eco J / An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.

In: Behavior Genetics, Vol. 48, No. 1, 01.01.2018, p. 1-11.

Research output: Scientific - peer-reviewArticle

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An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. / Boomsma, Dorret I; Helmer, Quinta; Nieuwboer, Harold A; Hottenga, Jouke Jan; de Moor, Marleen H; van den Berg, Stéphanie M; Davies, Gareth E; Vink, Jacqueline M; Schouten, Maarten J; Dolan, Conor V; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, C.E.M.; Ligthart, Lannie; de Geus, Eco J.

In: Behavior Genetics, Vol. 48, No. 1, 01.01.2018, p. 1-11.

Research output: Scientific - peer-reviewArticle

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