An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Dorret I Boomsma; Quinta Helmer; Harold A Nieuwboer; Jouke Jan Hottenga; Marleen H de Moor; Stéphanie M van den Berg; Gareth E Davies; Jacqueline M Vink; Maarten J Schouten; Conor V Dolan; Gonneke Willemsen; Meike Bartels; C.E.M. van Beijsterveldt; Lannie Ligthart; Eco J de Geus

doi:10.1007/s10519-017-9872-0

An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Dorret I Boomsma, Quinta Helmer, Harold A Nieuwboer, Jouke Jan Hottenga, Marleen H de Moor, Stéphanie M van den Berg, Gareth E Davies, Jacqueline M Vink, Maarten J Schouten, Conor V Dolan, Gonneke Willemsen, Meike Bartels, C.E.M. van Beijsterveldt, Lannie Ligthart, Eco J de Geus

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Abstract

For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores. We analyzed these data in the Mendel software package (Lange et al., Bioinformatics 29(12):1568-1570, 2013) to estimate the contributions of additive and non-additive genetic factors. In contrast to much of the earlier work based on twin data rather than on extended pedigrees, we could also estimate the contribution of shared household effects in the presence of non-additive genetic factors. The estimated broad-sense heritability of neuroticism was 47%, with almost equal contributions of additive and non-additive (dominance) genetic factors. A shared household effect explained 13% and unique environmental factors explained the remaining 40% of the variance in neuroticism.

Original language	English
Pages (from-to)	1-11
Journal	Behavior Genetics
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/s10519-017-9872-0
Publication status	Published - 1 Jan 2018

Funding

HN was supported by Royal Netherlands Academy of Science Professor Award (PAH/6635) to DIB, and by a University Research Fellow (URF) of the Vrije Universiteit, Amsterdam. Data collection and zygosity typing were made possible by multiple grants from the Netherlands Organization for Scientific Research (NWO): 575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192 and the Avera Institute for Human Genetics. We gratefully acknowledge grant NWO 480-15-001/674: Netherlands Twin Registry Repository: researching the interplay between genome and environment. Dorret I. Boomsma, Quinta Helmer, Harold A. Nieuwboer, Jouke Jan Hottenga, Marleen H. de Moor, Stéphanie M. van den Berg, Gareth E. Davies, Jacqueline M. Vink, Maarten J. Schouten, Conor V. Dolan, Gonneke Willemsen, Meike Bartels, Toos C. E. M. van Beijsterveldt, Lannie Ligthart, Eco J de Geus declare that they have no conflict of interest. Funding HN was supported by Royal Netherlands Academy of Science Professor Award (PAH/6635) to DIB, and by a University Research Fellow (URF) of the Vrije Universiteit, Amsterdam. Data collection and zygosity typing were made possible by multiple grants from the Netherlands Organization for Scientific Research (NWO): 575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192 and the Avera Institute for Human Genetics. We gratefully acknowledge grant NWO 480-15-001/674: Netherlands Twin Registry Repository: researching the interplay between genome and environment.

Funders	Funder number
Royal Netherlands Academy of Science	PAH/6635
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	311-60008, 480-04-004, 904-61-090, 400-05-717, 575-25-006, 904-61-193, SPI 56-464-14192
Avera Institute for Human Genetics	480-15-001/674

Keywords

Journal Article

Cohort Studies

Netherlands Twin Register (NTR)

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10.1007/s10519-017-9872-0

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Boomsma, D. I., Helmer, Q., Nieuwboer, H. A., Hottenga, J. J., de Moor, M. H., van den Berg, S. M., Davies, G. E., Vink, J. M., Schouten, M. J., Dolan, C. V., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ligthart, L., & de Geus, E. J. (2018). An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. Behavior Genetics, 48(1), 1-11. https://doi.org/10.1007/s10519-017-9872-0

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Boomsma, DI, Helmer, Q, Nieuwboer, HA, Hottenga, JJ, de Moor, MH, van den Berg, SM, Davies, GE, Vink, JM, Schouten, MJ, Dolan, CV , Willemsen, G , Bartels, M, van Beijsterveldt, CEM, Ligthart, L & de Geus, EJ 2018, 'An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register', Behavior Genetics, vol. 48, no. 1, pp. 1-11. https://doi.org/10.1007/s10519-017-9872-0

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AU - Schouten, Maarten J

AU - Dolan, Conor V

AU - Willemsen, Gonneke

AU - Bartels, Meike

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AU - Ligthart, Lannie

AU - de Geus, Eco J

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An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

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