The present paper gives an overview of recent research on the association between 2D:4D and different types of economic behavior. Particular attention is given to the importance of context dependence of relationships between 2D:4D and economic as well as other, social, behavior. Patterns of results are discussed from the perspective that 2D:4D might serve as a biological marker of dispositional dominance. This overview hopes to stimulate research from an interactionist perspective which focuses at relationships between 2D:4D and behavior that only appear when specific situational pressures interact with individual differences in 2D:4D. © 2010 Elsevier Ltd.