Analysis of concentration response curves to describe and compare tha antimicrobial activity anof model cationic alpha-helical peptides.

M. Rautenbach, G.D. Gerstner, N.M. Vlok, J. Kulenkampff, H.V. Westerhoff

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

To assess and compare different model Leu-Lys-containing cationic α-helical peptides, their antimicrobial activities were tested against Escherichia coli as target organism over a broad peptide concentration range. The natural cationic α-helical peptides magainin 2 and PGLa and the cyclic cationic peptide gramicidin S were also tested between comparison. The dose-response curves differed widely for these peptides, making it difficult to rank them into an activity order over the whole concentration range. We therefore compared five different inhibition parameters from dose-response curves: IC
Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalAnalytical Biochemistry
Volume350
DOIs
Publication statusPublished - 2006

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