Analysis of concentration response curves to describe and compare tha antimicrobial activity anof model cationic alpha-helical peptides.

M. Rautenbach; G.D. Gerstner; N.M. Vlok; J. Kulenkampff; H.V. Westerhoff

doi:10.1016/j.ab.2005.11.027

Analysis of concentration response curves to describe and compare tha antimicrobial activity anof model cationic alpha-helical peptides.

M. Rautenbach, G.D. Gerstner, N.M. Vlok, J. Kulenkampff, H.V. Westerhoff

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

To assess and compare different model Leu-Lys-containing cationic α-helical peptides, their antimicrobial activities were tested against Escherichia coli as target organism over a broad peptide concentration range. The natural cationic α-helical peptides magainin 2 and PGLa and the cyclic cationic peptide gramicidin S were also tested between comparison. The dose-response curves differed widely for these peptides, making it difficult to rank them into an activity order over the whole concentration range. We therefore compared five different inhibition parameters from dose-response curves: IC

Original language	English
Pages (from-to)	81-90
Number of pages	10
Journal	Analytical Biochemistry
Volume	350
DOIs	https://doi.org/10.1016/j.ab.2005.11.027
Publication status	Published - 2006

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10.1016/j.ab.2005.11.027

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title = "Analysis of concentration response curves to describe and compare tha antimicrobial activity anof model cationic alpha-helical peptides.",

abstract = "To assess and compare different model Leu-Lys-containing cationic α-helical peptides, their antimicrobial activities were tested against Escherichia coli as target organism over a broad peptide concentration range. The natural cationic α-helical peptides magainin 2 and PGLa and the cyclic cationic peptide gramicidin S were also tested between comparison. The dose-response curves differed widely for these peptides, making it difficult to rank them into an activity order over the whole concentration range. We therefore compared five different inhibition parameters from dose-response curves: IC",

author = "M. Rautenbach and G.D. Gerstner and N.M. Vlok and J. Kulenkampff and H.V. Westerhoff",

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language = "English",

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journal = "Analytical Biochemistry",

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AU - Vlok, N.M.

AU - Kulenkampff, J.

AU - Westerhoff, H.V.

PY - 2006

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AB - To assess and compare different model Leu-Lys-containing cationic α-helical peptides, their antimicrobial activities were tested against Escherichia coli as target organism over a broad peptide concentration range. The natural cationic α-helical peptides magainin 2 and PGLa and the cyclic cationic peptide gramicidin S were also tested between comparison. The dose-response curves differed widely for these peptides, making it difficult to rank them into an activity order over the whole concentration range. We therefore compared five different inhibition parameters from dose-response curves: IC

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DO - 10.1016/j.ab.2005.11.027

M3 - Article

SN - 0003-2697

VL - 350

SP - 81

EP - 90

JO - Analytical Biochemistry

JF - Analytical Biochemistry

ER -

Analysis of concentration response curves to describe and compare tha antimicrobial activity anof model cationic alpha-helical peptides.

Abstract

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