Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

Hussein Antar; Edem Tsikata; Kitiya Ratanawongphaibul; Jing Zhang; Eric Shieh; Ramon Lee; Madeline Freeman; Georgia Papadogeorgou; Huseyin Simavli; Christian Que; Alice C. Verticchio Vercellin; Ziad Khoueir; Johannes F. De Boer; Teresa C. Chen

doi:10.1097/IJG.0000000000001381

Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

Hussein Antar, Edem Tsikata, Kitiya Ratanawongphaibul, Jing Zhang, Eric Shieh, Ramon Lee, Madeline Freeman, Georgia Papadogeorgou, Huseyin Simavli, Christian Que, Alice C. Verticchio Vercellin, Ziad Khoueir, Johannes F. De Boer, Teresa C. Chen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Précis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P

Original language	English
Pages (from-to)	979-988
Number of pages	10
Journal	Journal of Glaucoma
Volume	28
Issue number	11
DOIs	https://doi.org/10.1097/IJG.0000000000001381
Publication status	Published - 1 Nov 2019

Funding

Disclosure: J.F.d.B. is the chair of the Scientific Advisory Board of the Center for Biomedical Optical Coherence Tomography Research and Translation (Harvard Medical School), and licenses to NIDEK Inc., Terumo Corporation, Ninepoint Medical, and Heidelberg Engineering, outside the submitted work. T.C.C. received funding from the following: American Glaucoma Society Mid-Career Award (San Francisco, CA), Massachusetts Lions Eye Research Fund, Fidelity Charitable Fund (Harvard University, Boston, MA), Harvard Catalyst Grant, National Institutes of Health UL RR025758 (Bethesda, MD), and Department of Defense Small Business Innovation Research DHP15-016. The remaining authors declare no conflict of interest.

Funders	Funder number
Fidelity Charitable Fund
National Institutes of Health
National Center for Research Resources	UL1RR025758
Small Business Innovation Research	DHP15-016
Massachusetts Lions Eye Research Fund
American Glaucoma Society

Keywords

neuroretinal rim
optic nerve
optical coherence tomography

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10.1097/IJG.0000000000001381

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Antar, H., Tsikata, E., Ratanawongphaibul, K., Zhang, J., Shieh, E., Lee, R., Freeman, M., Papadogeorgou, G., Simavli, H., Que, C., Verticchio Vercellin, A. C., Khoueir, Z., De Boer, J. F., & Chen, T. C. (2019). Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography. Journal of Glaucoma, 28(11), 979-988. https://doi.org/10.1097/IJG.0000000000001381

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title = "Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography",

abstract = "Pr{\'e}cis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P",

keywords = "neuroretinal rim, optic nerve, optical coherence tomography",

author = "Hussein Antar and Edem Tsikata and Kitiya Ratanawongphaibul and Jing Zhang and Eric Shieh and Ramon Lee and Madeline Freeman and Georgia Papadogeorgou and Huseyin Simavli and Christian Que and {Verticchio Vercellin}, {Alice C.} and Ziad Khoueir and {De Boer}, {Johannes F.} and Chen, {Teresa C.}",

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doi = "10.1097/IJG.0000000000001381",

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Antar, H, Tsikata, E, Ratanawongphaibul, K, Zhang, J, Shieh, E, Lee, R, Freeman, M, Papadogeorgou, G, Simavli, H, Que, C, Verticchio Vercellin, AC, Khoueir, Z, De Boer, JF & Chen, TC 2019, 'Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography', Journal of Glaucoma, vol. 28, no. 11, pp. 979-988. https://doi.org/10.1097/IJG.0000000000001381

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T1 - Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

AU - Antar, Hussein

AU - Tsikata, Edem

AU - Ratanawongphaibul, Kitiya

AU - Zhang, Jing

AU - Shieh, Eric

AU - Lee, Ramon

AU - Freeman, Madeline

AU - Papadogeorgou, Georgia

AU - Simavli, Huseyin

AU - Que, Christian

AU - Verticchio Vercellin, Alice C.

AU - Khoueir, Ziad

AU - De Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Précis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P

AB - Précis:Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes.Purpose:To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes.Methods:A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim MDB thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a 3-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane and the termination of the retinal pigment epithelium/Bruch's membrane complex. Multiple linear regression analysis was performed to determine the associations of age, race, and sex with neuroretinal rim MDB measurements.Results:The population was 57% female and 69% white with a mean age of 58.415.3 years. The mean MDB thickness in the normal population was 278.447.5 m. For this normal population, MDB thickness decreased by 0.84 m annually (P

KW - neuroretinal rim

KW - optic nerve

KW - optical coherence tomography

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DO - 10.1097/IJG.0000000000001381

M3 - Article

SN - 1057-0829

VL - 28

SP - 979

EP - 988

JO - Journal of Glaucoma

JF - Journal of Glaucoma

IS - 11

ER -

Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

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