Analysis of perfluorinated compounds in biota by microextraction with tetrahydrofuran and liquid chromatography/ion isolation-based ion-trap mass spectrometry

N. Luque; A. Ballesteros-Gómez; S.P.J. van Leeuwen; S. Rubio

doi:10.1016/j.chroma.2010.04.014

Analysis of perfluorinated compounds in biota by microextraction with tetrahydrofuran and liquid chromatography/ion isolation-based ion-trap mass spectrometry

N. Luque, A. Ballesteros-Gómez, S.P.J. van Leeuwen, S. Rubio

Chemistry and Biology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

An analytical method combining both a simple, fast and efficient solvent microextraction and a sensitive and selective monitoring mode, based on ion isolation ion-trap mass spectrometry (MS), was developed for analysis of perfluorinated compounds (PFCs) in biota. The method involved the vortex-shaking of 0.2g of tissue sample and 800μL of tetrahydrofuran (THF):water (75:25, v/v) for 7min, subsequent centrifugation for 13min and direct quantitation of PFCs in the extract against solvent-based calibration curves. Selection of solvent composition was based on Hildebrand solubility parameters and their components (i.e. dispersion, dipole-dipole and hydrogen bonding forces). Recoveries in samples for PFCs with hydrocarbon chain lengths between C

Original language	English
Pages (from-to)	3774-3782
Journal	Journal of Chromatography A
Volume	1217
Issue number	24
DOIs	https://doi.org/10.1016/j.chroma.2010.04.014
Publication status	Published - 2010

Bibliographical note

J 1

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Luque, N., Ballesteros-Gómez, A., van Leeuwen, S. P. J., & Rubio, S. (2010). Analysis of perfluorinated compounds in biota by microextraction with tetrahydrofuran and liquid chromatography/ion isolation-based ion-trap mass spectrometry. Journal of Chromatography A, 1217(24), 3774-3782. https://doi.org/10.1016/j.chroma.2010.04.014

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abstract = "An analytical method combining both a simple, fast and efficient solvent microextraction and a sensitive and selective monitoring mode, based on ion isolation ion-trap mass spectrometry (MS), was developed for analysis of perfluorinated compounds (PFCs) in biota. The method involved the vortex-shaking of 0.2g of tissue sample and 800μL of tetrahydrofuran (THF):water (75:25, v/v) for 7min, subsequent centrifugation for 13min and direct quantitation of PFCs in the extract against solvent-based calibration curves. Selection of solvent composition was based on Hildebrand solubility parameters and their components (i.e. dispersion, dipole-dipole and hydrogen bonding forces). Recoveries in samples for PFCs with hydrocarbon chain lengths between C",

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Analysis of perfluorinated compounds in biota by microextraction with tetrahydrofuran and liquid chromatography/ion isolation-based ion-trap mass spectrometry. / Luque, N.; Ballesteros-Gómez, A.; van Leeuwen, S.P.J.; Rubio, S.

In: Journal of Chromatography A, Vol. 1217, No. 24, 2010, p. 3774-3782.

Research output: Contribution to Journal › Article › Academic › peer-review

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AU - van Leeuwen, S.P.J.

AU - Rubio, S.

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