Analysis of perfluorinated compounds in biota by microextraction with tetrahydrofuran and liquid chromatography/ion isolation-based ion-trap mass spectrometry

N. Luque, A. Ballesteros-Gómez, S.P.J. van Leeuwen, S. Rubio

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

An analytical method combining both a simple, fast and efficient solvent microextraction and a sensitive and selective monitoring mode, based on ion isolation ion-trap mass spectrometry (MS), was developed for analysis of perfluorinated compounds (PFCs) in biota. The method involved the vortex-shaking of 0.2g of tissue sample and 800μL of tetrahydrofuran (THF):water (75:25, v/v) for 7min, subsequent centrifugation for 13min and direct quantitation of PFCs in the extract against solvent-based calibration curves. Selection of solvent composition was based on Hildebrand solubility parameters and their components (i.e. dispersion, dipole-dipole and hydrogen bonding forces). Recoveries in samples for PFCs with hydrocarbon chain lengths between C
Original languageEnglish
Pages (from-to)3774-3782
JournalJournal of Chromatography A
Volume1217
Issue number24
DOIs
Publication statusPublished - 2010

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