Analyte-deposition-based detection in column liquid chromatography: concept and examples.

C. Gooijer, U.A.T. Brinkman, G.W. Somsen

Research output: Contribution to JournalArticleAcademicpeer-review


Column liquid chromatography (LC) is a powerful tool for the separation of constituents of complex mixtures and it can handle a wide range of sample types and analyte classes. Today, the on-line combination of LC and a spectrometric detection technique for analyte quantification as well as identification purposes is a powerful and well-known approach. However, there are also situations in which the separation and detection conditions are not at all compatible. Semi on-line coupling via intermediate analyte deposition on a suitable substrate then offers an elegant solution, as will be described in some detail in the present review.
Original languageEnglish
Pages (from-to)129
JournalTrAC. Trends in Analytical Chemistry
Publication statusPublished - 1998


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