Analytical model for diffuse reflectance in single fiber reflectance spectroscopy

Dirk J. Faber; Anouk L. Post; Henricus J.C.M. Sterenborg; Ton G. van Leeuwen

doi:10.1364/OL.385845

Analytical model for diffuse reflectance in single fiber reflectance spectroscopy

Dirk J. Faber, Anouk L. Post, Henricus J.C.M. Sterenborg, Ton G. van Leeuwen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Cancer progression leads to changing scattering properties of affected tissues. Single fiber reflectance (SFR) spectroscopy detects these changes at small spatial scales, making it a promising tool for early in situ detection. Despite its simplicity and versatility, SFR signal modeling is hugely complicated so that, presently, only approximate models exist. We use a classic approach from geometrical probability to derive accurate analytical expressions for diffuse reflectance in SFR that shows a strong improvement over existing models. We consider the case of limited collection efficiency and the presence of absorption. A Monte Carlo light transport study demonstrates that we adequately describe the contribution of diffuse reflectance to the SFR signal. Additional steps are required to include semi-ballistic, non-diffuse reflectance also present in the SFR measurement.

Original language	English
Pages (from-to)	2078-2081
Journal	Optics Letters
Volume	45
Issue number	7
DOIs	https://doi.org/10.1364/OL.385845
Publication status	Published - 1 Apr 2020
Externally published	Yes

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (12707).

Funders	Funder number
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	12707

Access to Document

10.1364/OL.385845

Persistent URL (handle)

Persistent link

Cite this

@article{1e3aee0b4b4a4bdd826f76c1630a93af,

title = "Analytical model for diffuse reflectance in single fiber reflectance spectroscopy",

abstract = "Cancer progression leads to changing scattering properties of affected tissues. Single fiber reflectance (SFR) spectroscopy detects these changes at small spatial scales, making it a promising tool for early in situ detection. Despite its simplicity and versatility, SFR signal modeling is hugely complicated so that, presently, only approximate models exist. We use a classic approach from geometrical probability to derive accurate analytical expressions for diffuse reflectance in SFR that shows a strong improvement over existing models. We consider the case of limited collection efficiency and the presence of absorption. A Monte Carlo light transport study demonstrates that we adequately describe the contribution of diffuse reflectance to the SFR signal. Additional steps are required to include semi-ballistic, non-diffuse reflectance also present in the SFR measurement.",

author = "Faber, {Dirk J.} and Post, {Anouk L.} and Sterenborg, {Henricus J.C.M.} and {van Leeuwen}, {Ton G.}",

year = "2020",

month = apr,

day = "1",

doi = "10.1364/OL.385845",

language = "English",

volume = "45",

pages = "2078--2081",

journal = "Optics Letters",

issn = "0146-9592",

publisher = "The Optical Society",

number = "7",

}

TY - JOUR

T1 - Analytical model for diffuse reflectance in single fiber reflectance spectroscopy

AU - Faber, Dirk J.

AU - Post, Anouk L.

AU - Sterenborg, Henricus J.C.M.

AU - van Leeuwen, Ton G.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Cancer progression leads to changing scattering properties of affected tissues. Single fiber reflectance (SFR) spectroscopy detects these changes at small spatial scales, making it a promising tool for early in situ detection. Despite its simplicity and versatility, SFR signal modeling is hugely complicated so that, presently, only approximate models exist. We use a classic approach from geometrical probability to derive accurate analytical expressions for diffuse reflectance in SFR that shows a strong improvement over existing models. We consider the case of limited collection efficiency and the presence of absorption. A Monte Carlo light transport study demonstrates that we adequately describe the contribution of diffuse reflectance to the SFR signal. Additional steps are required to include semi-ballistic, non-diffuse reflectance also present in the SFR measurement.

AB - Cancer progression leads to changing scattering properties of affected tissues. Single fiber reflectance (SFR) spectroscopy detects these changes at small spatial scales, making it a promising tool for early in situ detection. Despite its simplicity and versatility, SFR signal modeling is hugely complicated so that, presently, only approximate models exist. We use a classic approach from geometrical probability to derive accurate analytical expressions for diffuse reflectance in SFR that shows a strong improvement over existing models. We consider the case of limited collection efficiency and the presence of absorption. A Monte Carlo light transport study demonstrates that we adequately describe the contribution of diffuse reflectance to the SFR signal. Additional steps are required to include semi-ballistic, non-diffuse reflectance also present in the SFR measurement.

UR - http://www.scopus.com/inward/record.url?scp=85082767597&partnerID=8YFLogxK

U2 - 10.1364/OL.385845

DO - 10.1364/OL.385845

M3 - Article

SN - 0146-9592

VL - 45

SP - 2078

EP - 2081

JO - Optics Letters

JF - Optics Letters

IS - 7

ER -

Analytical model for diffuse reflectance in single fiber reflectance spectroscopy

Abstract

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this