Analyzing interactions on combining multiple clinical guidelines

Veruska Zamborlini*, Marcos Da Silveira, Cedric Pruski, Annette ten Teije, Edwin Geleijn, Marike van der Leeden, Martijn Stuiver, Frank van Harmelen

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

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Accounting for patients with multiple health conditions is a complex task that requires analysing potential interactions among recommendations meant to address each condition. Although some approaches have been proposed to address this issue, important features still require more investigation, such as (re)usability and scalability. To this end, this paper presents an approach that relies on reusable rules for detecting interactions among recommendations coming from various guidelines. It extends a previously proposed knowledge representation model (TMR) to enhance the detection of interactions and it provides a systematic analysis of relevant interactions in the context of multimorbidity. The approach is evaluated in a case study on rehabilitation of breast cancer patients, developed in collaboration with experts. The results are considered promising to support the experts in this task.

Original languageEnglish
Pages (from-to)78-93
Number of pages16
JournalArtificial Intelligence in Medicine
Early online date11 Apr 2017
Publication statusPublished - Sept 2017


  • Clinical knowledge representation
  • Combining clinical guidelines
  • Comorbidity
  • Interactions among guidelines
  • Multimorbidity


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