Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

F. Hagen, P.C. Ceresini, I. Polacheck, H. Ma, F. van Nieuwerburgh, T. Gabaldón, S. Kagan, E.R. Pursall, H.L. Hoogveld, L.J.J. van Iersel, G.W. Klau, S.M. Kelk, K.H. Bartlett, L. Stougie, K. Voelz, L.P. Pryszcz, E. Castañeda, M. Lazera, W. Mey, D. Deforce & 4 others J.F. Meis, R.C. May, C.H.W. Klaassen, T. Boekhout

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals. © 2013 Hagen et al.
LanguageEnglish
Pagese71148
Number of pages14
JournalPLoS ONE
Volume8
Issue number8
Early online date1 Jul 2013
DOIs
Publication statusPublished - 2013

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Cryptococcus gattii
Pathogens
Amazonia
Disease Outbreaks
Animals
pathogens
Coalescence
Genes
Tropical Climate
Northwestern United States
Genealogy and Heraldry
South America
subtropics
Islands
Genetic Recombination
amplified fragment length polymorphism
rain forests
Brazil
tropics
animals

Cite this

Hagen, F., Ceresini, P. C., Polacheck, I., Ma, H., van Nieuwerburgh, F., Gabaldón, T., ... Boekhout, T. (2013). Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest. PLoS ONE, 8(8), e71148. https://doi.org/10.1371/journal.pone.0071148
Hagen, F. ; Ceresini, P.C. ; Polacheck, I. ; Ma, H. ; van Nieuwerburgh, F. ; Gabaldón, T. ; Kagan, S. ; Pursall, E.R. ; Hoogveld, H.L. ; van Iersel, L.J.J. ; Klau, G.W. ; Kelk, S.M. ; Bartlett, K.H. ; Stougie, L. ; Voelz, K. ; Pryszcz, L.P. ; Castañeda, E. ; Lazera, M. ; Mey, W. ; Deforce, D. ; Meis, J.F. ; May, R.C. ; Klaassen, C.H.W. ; Boekhout, T. / Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest. In: PLoS ONE. 2013 ; Vol. 8, No. 8. pp. e71148.
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Hagen, F, Ceresini, PC, Polacheck, I, Ma, H, van Nieuwerburgh, F, Gabaldón, T, Kagan, S, Pursall, ER, Hoogveld, HL, van Iersel, LJJ, Klau, GW, Kelk, SM, Bartlett, KH, Stougie, L, Voelz, K, Pryszcz, LP, Castañeda, E, Lazera, M, Mey, W, Deforce, D, Meis, JF, May, RC, Klaassen, CHW & Boekhout, T 2013, 'Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest', PLoS ONE, vol. 8, no. 8, pp. e71148. https://doi.org/10.1371/journal.pone.0071148

Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest. / Hagen, F.; Ceresini, P.C.; Polacheck, I.; Ma, H.; van Nieuwerburgh, F.; Gabaldón, T.; Kagan, S.; Pursall, E.R.; Hoogveld, H.L.; van Iersel, L.J.J.; Klau, G.W.; Kelk, S.M.; Bartlett, K.H.; Stougie, L.; Voelz, K.; Pryszcz, L.P.; Castañeda, E.; Lazera, M.; Mey, W.; Deforce, D.; Meis, J.F.; May, R.C.; Klaassen, C.H.W.; Boekhout, T.

In: PLoS ONE, Vol. 8, No. 8, 2013, p. e71148.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Ceresini, P.C.

AU - Polacheck, I.

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AU - Kagan, S.

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AU - Deforce, D.

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Hagen F, Ceresini PC, Polacheck I, Ma H, van Nieuwerburgh F, Gabaldón T et al. Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest. PLoS ONE. 2013;8(8):e71148. https://doi.org/10.1371/journal.pone.0071148