Animal models of tuberculosis: Zebrafish

L.M. van Leeuwen, A.M. van der Sar, W. Bitter

Research output: Contribution to JournalArticleAcademicpeer-review


Over the past decade the zebrafish (Danio rerio) has become an attractive new vertebrate model organism for studying mycobacterial pathogenesis. The combination of mediumthroughput screening and real-time in vivo visualization has allowed new ways to dissect host pathogenic interaction in a vertebrate host. Furthermore, genetic screens on the host and bacterial sides have elucidated new mechanisms involved in the initiation of granuloma formation and the importance of a balanced immune response for control of mycobacterial pathogens. This article will highlight the unique features of the zebrafish-Mycobacterium marinum infection model and its added value for tuberculosis research.
Original languageEnglish
Article numbera018580
JournalCold Spring Harbor perspectives in medicine
Issue number3
Publication statusAccepted/In press - 2015


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