Anthrax protective antigen is a calcium-dependent serine protease

L. Storm; F.J. Bikker; K. Nazmi; A.G. Hulst; D.V. der Riet-van Oeveren; E.C.I. Veerman; J.P. Hays; W.E. Kaman

doi:10.1080/21505594.2018.1486139

Anthrax protective antigen is a calcium-dependent serine protease

L. Storm, F.J. Bikker, K. Nazmi, A.G. Hulst, D.V. der Riet-van Oeveren, E.C.I. Veerman, J.P. Hays, W.E. Kaman

Oral Biochemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. Additionally our findings shed new light on previous research describing the inhibition of anthrax toxins and exotoxin formation. Importantly, inhibition of the proteolytic activity of protective antigen could be a novel therapeutic strategy in fighting B. anthracis-related infections.

Original language	English
Pages (from-to)	1085-1091
Journal	Virulence
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/21505594.2018.1486139
Publication status	Published - 2018

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abstract = "Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. Additionally our findings shed new light on previous research describing the inhibition of anthrax toxins and exotoxin formation. Importantly, inhibition of the proteolytic activity of protective antigen could be a novel therapeutic strategy in fighting B. anthracis-related infections.",

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AU - Storm, L.

AU - Bikker, F.J.

AU - Nazmi, K.

AU - Hulst, A.G.

AU - der Riet-van Oeveren, D.V.

AU - Veerman, E.C.I.

AU - Hays, J.P.

AU - Kaman, W.E.

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JO - Virulence

JF - Virulence

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ER -

Anthrax protective antigen is a calcium-dependent serine protease

Abstract

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