Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis

Yang Zhang, Lei Huang, Jinmei Zhang, Alessandra Nara De Souza Rastelli, Jingmei Yang*, Dongmei Deng

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Objective: Curcumin has been used as an adjunct to non-surgical periodontal treatment. However, the efficacy of curcumin in the periodontal therapy remained controversial. This study aimed to evaluate the anti-inflammatory efficacy of curcumin as an adjunct to non-surgical periodontal treatment (NPT) by systematic review. Methods: Databases including Embase, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched to identify relevant RCTs on the use of curcumin as an adjunct to NPT for the treatment of periodontal disease from inception to July 21, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed using Review Manager 5.3 software. Results: A total of 18 RCTs involving 846 patients/sites were included in this meta-analysis. The results of the meta-analysis revealed that as compared to NPT alone, curcumin as an adjunct to NPT resulted in significant reduction in gingival index (GI) at the 1-week (mean differences (MD) = −0.15, 95% confidence intervals (CI) −0.26 to −0.05, p = 0.005), 2-week (MD = −0.51, 95%CI −0.74 to −0.28, p < 0.0001), 3-week (MD = −0.34, 95%CI −0.66 to −0.02, p = 0.03), 4-week (MD = −0.25, 95%CI −0.48 to −0.02, p = 0.04) or 6-week (MD = −0.33, 95%CI −0.58 to −0.08, p = 0.01) follow-ups. Similar significant reductions were also observed for sulcus bleeding index (SBI) at 1, 2, 4, and 12 weeks. However, there were no statistically significant differences in reducing bleeding on probing (BOP) between curcumin as an adjunct and NPT alone at 4, 12, and 24 weeks. Conclusion: Based on the current evidence, curcumin demonstrates anti-inflammatory efficacies in terms of reducing GI and SBI compared with NPT alone. Moreover, curcumin is a natural herbal medicine with few side effects, and it is a good candidate as an adjunct treatment for periodontal disease.

Original languageEnglish
Article number808460
Pages (from-to)1-15
Number of pages15
JournalFrontiers in Pharmacology
Volume13
Issue numberJanuary
Early online date24 Jan 2022
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

Funding Information:
This study was funded by the Science and Technology Department of Sichuan Province (No. 22ZDYF1311), and Research and Development Foundation of West China Hospital of Stomatology, Sichuan University (No. RD-02-201905).

Publisher Copyright:
Copyright © 2022 Zhang, Huang, Zhang, De Souza Rastelli, Yang and Deng.

Funding

This study was funded by the Science and Technology Department of Sichuan Province (No. 22ZDYF1311), and Research and Development Foundation of West China Hospital of Stomatology, Sichuan University (No. RD-02-201905).

FundersFunder number
Research and Development Foundation of West China Hospital of Stomatology
Department of Science and Technology of Sichuan Province22ZDYF1311
Department of Science and Technology of Sichuan Province
Sichuan UniversityRD-02-201905
Sichuan University

    Keywords

    • anti-inflammatory
    • curcumin
    • meta-analysis
    • non-surgical periodontal treatment (NPT)
    • periodontal disease

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