APOE and immunity: Research highlights

Courtney M. Kloske; Christopher J. Barnum; Andre F. Batista; Elizabeth M. Bradshaw; Adam M. Brickman; Guojun Bu; Jessica Dennison; Mary D. Gearon; Alison M. Goate; Christian Haass; Michael T. Heneka; William T. Hu; Lenique K.L. Huggins; Nahdia S. Jones; Radosveta Koldamova; Cynthia A. Lemere; Shane A. Liddelow; Edoardo Marcora; Samuel E. Marsh; Henrietta M. Nielsen; Kellen K. Petersen; Melissa Petersen; Stefanie D. Piña-Escudero; Wei Qiao Qiu; Yakeel T. Quiroz; Eric Reiman; Claire Sexton; Malú Gámez Tansey; Julia Tcw; Charlotte E. Teunissen; Betty M. Tijms; Rik van der Kant; Rebecca Wallings; Stacie C. Weninger; Whitney Wharton; Donna M. Wilcock; Tyler James Wishard; Susan L. Worley; Henrik Zetterberg; Maria C. Carrillo

doi:10.1002/alz.13020

APOE and immunity: Research highlights

Courtney M. Kloske^*, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K.L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. NielsenKellen K. Petersen, Melissa Petersen, Stefanie D. Piña-Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia Tcw, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L. Worley, Henrik Zetterberg, Maria C. Carrillo

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

Original language	English
Pages (from-to)	2677-2696
Number of pages	20
Journal	Alzheimer's and Dementia
Volume	19
Issue number	6
Early online date	28 Mar 2023
DOIs	https://doi.org/10.1002/alz.13020
Publication status	Published - Jun 2023

Bibliographical note

Funding Information:
The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443.

Publisher Copyright:
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Funding

The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443.

Funders	Funder number
Methods for the Treatment of Alzheimer's Disease	88800730-000443
National Institutes of Health
National Institute on Aging	1RF1AG058852 04/15/2018 – 03/31/2023
National Institute on Aging
Alzheimer's Association
ALS Association
Parkinson's Disease Foundation	5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, 1R21AG073882 08/15/2021 – 07/31/2023, 5U01AG061356 09/30/2018 – 08/31/2023, PF-RCE-1948 07/01/2019 – 06/30/2023
Parkinson's Disease Foundation
Infectious Diseases Society of America	CU21-3089 01/24/2022 – 12/24/2022, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang
Infectious Diseases Society of America

Keywords

Alzheimer's disease
amyloid beta
APOE
astrocytes
biomarkers
dementia
inflammation
microglia
neurodegeneration
neuroglia
neuroinflammation
tau
TREM2

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Kloske, C. M., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Brickman, A. M., Bu, G., Dennison, J., Gearon, M. D., Goate, A. M., Haass, C., Heneka, M. T., Hu, W. T., Huggins, L. K. L., Jones, N. S., Koldamova, R., Lemere, C. A., Liddelow, S. A., Marcora, E., Marsh, S. E., ... Carrillo, M. C. (2023). APOE and immunity: Research highlights. Alzheimer's and Dementia, 19(6), 2677-2696. https://doi.org/10.1002/alz.13020

@article{9e4a50efd8824fd7a5c47dd315c96704,

title = "APOE and immunity: Research highlights",

abstract = "INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.",

keywords = "Alzheimer's disease, amyloid beta, APOE, astrocytes, biomarkers, dementia, inflammation, microglia, neurodegeneration, neuroglia, neuroinflammation, tau, TREM2",

author = "Kloske, {Courtney M.} and Barnum, {Christopher J.} and Batista, {Andre F.} and Bradshaw, {Elizabeth M.} and Brickman, {Adam M.} and Guojun Bu and Jessica Dennison and Gearon, {Mary D.} and Goate, {Alison M.} and Christian Haass and Heneka, {Michael T.} and Hu, {William T.} and Huggins, {Lenique K.L.} and Jones, {Nahdia S.} and Radosveta Koldamova and Lemere, {Cynthia A.} and Liddelow, {Shane A.} and Edoardo Marcora and Marsh, {Samuel E.} and Nielsen, {Henrietta M.} and Petersen, {Kellen K.} and Melissa Petersen and Pi{\~n}a-Escudero, {Stefanie D.} and Qiu, {Wei Qiao} and Quiroz, {Yakeel T.} and Eric Reiman and Claire Sexton and Tansey, {Mal{\'u} G{\'a}mez} and Julia Tcw and Teunissen, {Charlotte E.} and Tijms, {Betty M.} and {van der Kant}, Rik and Rebecca Wallings and Weninger, {Stacie C.} and Whitney Wharton and Wilcock, {Donna M.} and Wishard, {Tyler James} and Worley, {Susan L.} and Henrik Zetterberg and Carrillo, {Maria C.}",

note = "Funding Information: The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443. Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = jun,

doi = "10.1002/alz.13020",

language = "English",

volume = "19",

pages = "2677--2696",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "6",

}

Kloske, CM, Barnum, CJ, Batista, AF, Bradshaw, EM, Brickman, AM, Bu, G, Dennison, J, Gearon, MD, Goate, AM, Haass, C, Heneka, MT, Hu, WT, Huggins, LKL, Jones, NS, Koldamova, R, Lemere, CA, Liddelow, SA, Marcora, E, Marsh, SE, Nielsen, HM, Petersen, KK, Petersen, M, Piña-Escudero, SD, Qiu, WQ, Quiroz, YT, Reiman, E, Sexton, C, Tansey, MG, Tcw, J, Teunissen, CE, Tijms, BM, van der Kant, R, Wallings, R, Weninger, SC, Wharton, W, Wilcock, DM, Wishard, TJ, Worley, SL, Zetterberg, H & Carrillo, MC 2023, 'APOE and immunity: Research highlights', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696. https://doi.org/10.1002/alz.13020

TY - JOUR

T1 - APOE and immunity: Research highlights

AU - Kloske, Courtney M.

AU - Barnum, Christopher J.

AU - Batista, Andre F.

AU - Bradshaw, Elizabeth M.

AU - Brickman, Adam M.

AU - Bu, Guojun

AU - Dennison, Jessica

AU - Gearon, Mary D.

AU - Goate, Alison M.

AU - Haass, Christian

AU - Heneka, Michael T.

AU - Hu, William T.

AU - Huggins, Lenique K.L.

AU - Jones, Nahdia S.

AU - Koldamova, Radosveta

AU - Lemere, Cynthia A.

AU - Liddelow, Shane A.

AU - Marcora, Edoardo

AU - Marsh, Samuel E.

AU - Nielsen, Henrietta M.

AU - Petersen, Kellen K.

AU - Petersen, Melissa

AU - Piña-Escudero, Stefanie D.

AU - Qiu, Wei Qiao

AU - Quiroz, Yakeel T.

AU - Reiman, Eric

AU - Sexton, Claire

AU - Tansey, Malú Gámez

AU - Tcw, Julia

AU - Teunissen, Charlotte E.

AU - Tijms, Betty M.

AU - van der Kant, Rik

AU - Wallings, Rebecca

AU - Weninger, Stacie C.

AU - Wharton, Whitney

AU - Wilcock, Donna M.

AU - Wishard, Tyler James

AU - Worley, Susan L.

AU - Zetterberg, Henrik

AU - Carrillo, Maria C.

N1 - Funding Information: The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2023/6

Y1 - 2023/6

N2 - INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

AB - INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

KW - Alzheimer's disease

KW - amyloid beta

KW - APOE

KW - astrocytes

KW - biomarkers

KW - dementia

KW - inflammation

KW - microglia

KW - neurodegeneration

KW - neuroglia

KW - neuroinflammation

KW - tau

KW - TREM2

UR - http://www.scopus.com/inward/record.url?scp=85151470933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85151470933&partnerID=8YFLogxK

U2 - 10.1002/alz.13020

DO - 10.1002/alz.13020

M3 - Review article

C2 - 36975090

AN - SCOPUS:85151470933

SN - 1552-5260

VL - 19

SP - 2677

EP - 2696

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 6

ER -

APOE and immunity: Research highlights

Abstract

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