Abstract
Counter-conditioning can be a valid strategy to reduce reinstatement of reward-seeking behavior. However, this has not been tested in laboratory animals with extended cocaine-taking backgrounds nor is it well understood, which individual differences may contribute to its effects. Here, we set out to investigate the influence of serotonin transporter (5-HTT) genotype on the effectiveness of counter-conditioning after extended access to cocaine self-administration. To this end, 5-HTT+/+ and 5-HTT−/− rats underwent a touch screen-based approach to test if reward-induced reinstatement of responding to a previously counter-conditioned cue is reduced, compared with a non-counter-conditioned cue, in a within-subject manner. We observed an overall extinction deficit of cocaine-seeking behavior in 5-HTT−/− rats and a resistance to punishment during the counter-conditioning session. Furthermore, we observed a significant decrease in reinstatement to cocaine and sucrose associated cues after counter-conditioning but only in 5-HTT+/+ rats. In short, we conclude that the paradigm we used was able to produce effects of counter-conditioning of sucrose seeking behavior in line with what is described in literature, and we demonstrate that it can be effective even after long-term exposure to cocaine, in a genotype-dependent manner.
| Original language | English |
|---|---|
| Pages (from-to) | 344-354 |
| Number of pages | 11 |
| Journal | Addiction Biology |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
| Externally published | Yes |
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Keywords
- cocaine
- counter-conditioning
- reinstatement
- serotonin transporter
- touch-screen
Cite this
}
Appetitive to aversive counter-conditioning as intervention to reduce reinstatement of reward-seeking behavior : the role of the serotonin transporter. / Karel, Peter; Almacellas-Barbanoj, Amanda; Prijn, Jeffrey; Kaag, Anne Marije; Reneman, Liesbeth; Verheij, Michel M.M.; Homberg, Judith R.
In: Addiction Biology, Vol. 24, No. 3, 01.05.2019, p. 344-354.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Appetitive to aversive counter-conditioning as intervention to reduce reinstatement of reward-seeking behavior
T2 - the role of the serotonin transporter
AU - Karel, Peter
AU - Almacellas-Barbanoj, Amanda
AU - Prijn, Jeffrey
AU - Kaag, Anne Marije
AU - Reneman, Liesbeth
AU - Verheij, Michel M.M.
AU - Homberg, Judith R.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Counter-conditioning can be a valid strategy to reduce reinstatement of reward-seeking behavior. However, this has not been tested in laboratory animals with extended cocaine-taking backgrounds nor is it well understood, which individual differences may contribute to its effects. Here, we set out to investigate the influence of serotonin transporter (5-HTT) genotype on the effectiveness of counter-conditioning after extended access to cocaine self-administration. To this end, 5-HTT+/+ and 5-HTT−/− rats underwent a touch screen-based approach to test if reward-induced reinstatement of responding to a previously counter-conditioned cue is reduced, compared with a non-counter-conditioned cue, in a within-subject manner. We observed an overall extinction deficit of cocaine-seeking behavior in 5-HTT−/− rats and a resistance to punishment during the counter-conditioning session. Furthermore, we observed a significant decrease in reinstatement to cocaine and sucrose associated cues after counter-conditioning but only in 5-HTT+/+ rats. In short, we conclude that the paradigm we used was able to produce effects of counter-conditioning of sucrose seeking behavior in line with what is described in literature, and we demonstrate that it can be effective even after long-term exposure to cocaine, in a genotype-dependent manner.
AB - Counter-conditioning can be a valid strategy to reduce reinstatement of reward-seeking behavior. However, this has not been tested in laboratory animals with extended cocaine-taking backgrounds nor is it well understood, which individual differences may contribute to its effects. Here, we set out to investigate the influence of serotonin transporter (5-HTT) genotype on the effectiveness of counter-conditioning after extended access to cocaine self-administration. To this end, 5-HTT+/+ and 5-HTT−/− rats underwent a touch screen-based approach to test if reward-induced reinstatement of responding to a previously counter-conditioned cue is reduced, compared with a non-counter-conditioned cue, in a within-subject manner. We observed an overall extinction deficit of cocaine-seeking behavior in 5-HTT−/− rats and a resistance to punishment during the counter-conditioning session. Furthermore, we observed a significant decrease in reinstatement to cocaine and sucrose associated cues after counter-conditioning but only in 5-HTT+/+ rats. In short, we conclude that the paradigm we used was able to produce effects of counter-conditioning of sucrose seeking behavior in line with what is described in literature, and we demonstrate that it can be effective even after long-term exposure to cocaine, in a genotype-dependent manner.
KW - cocaine
KW - counter-conditioning
KW - reinstatement
KW - serotonin transporter
KW - touch-screen
UR - http://www.scopus.com/inward/record.url?scp=85039701144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039701144&partnerID=8YFLogxK
U2 - 10.1111/adb.12596
DO - 10.1111/adb.12596
M3 - Article
VL - 24
SP - 344
EP - 354
JO - Addiction Biology
JF - Addiction Biology
SN - 1355-6215
IS - 3
ER -