Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

Harini Venkataraman, Marlies C. A. Verkade-Vreeker, Luigi Capoferri, Daan P. Geerke, Nico P. E. Vermeulen, Jan N. M. Commandeur

Research output: Contribution to JournalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)5613-5620
JournalBioorganic and Medicinal Chemistry
Issue number20
Publication statusPublished - 15 Oct 2014


  • Engineered enzymes
  • Biocatalysis
  • Regioselectivity
  • Total turnover numbers
  • Fenamic acid NSAIDs
  • Drug metabolites

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