Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

Harini Venkataraman; Marlies C. A. Verkade-Vreeker; Luigi Capoferri; Daan P. Geerke; Nico P. E. Vermeulen; Jan N. M. Commandeur

doi:10.1016/j.bmc.2014.06.022

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

Harini Venkataraman, Marlies C. A. Verkade-Vreeker, Luigi Capoferri, Daan P. Geerke, Nico P. E. Vermeulen, Jan N. M. Commandeur

Research output: Contribution to Journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	5613-5620
Journal	Bioorganic and Medicinal Chemistry
Volume	22
Issue number	20
DOIs	https://doi.org/10.1016/j.bmc.2014.06.022
Publication status	Published - 15 Oct 2014

Keywords

Engineered enzymes
Biocatalysis
Regioselectivity
Total turnover numbers
Fenamic acid NSAIDs
Drug metabolites

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10.1016/j.bmc.2014.06.022

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@article{8b0845c62c5a46b9a8d35b7bfc974923,

title = "Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs",

keywords = "Engineered enzymes, Biocatalysis, Regioselectivity, Total turnover numbers, Fenamic acid NSAIDs, Drug metabolites",

author = "Harini Venkataraman and Verkade-Vreeker, {Marlies C. A.} and Luigi Capoferri and Geerke, {Daan P.} and Vermeulen, {Nico P. E.} and Commandeur, {Jan N. M.}",

year = "2014",

month = oct,

day = "15",

doi = "10.1016/j.bmc.2014.06.022",

language = "English",

volume = "22",

pages = "5613--5620",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "20",

}

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. / Venkataraman, Harini; Verkade-Vreeker, Marlies C. A.; Capoferri, Luigi et al.
In: Bioorganic and Medicinal Chemistry, Vol. 22, No. 20, 15.10.2014, p. 5613-5620.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

AU - Venkataraman, Harini

AU - Verkade-Vreeker, Marlies C. A.

AU - Capoferri, Luigi

AU - Geerke, Daan P.

AU - Vermeulen, Nico P. E.

AU - Commandeur, Jan N. M.

PY - 2014/10/15

Y1 - 2014/10/15

KW - Engineered enzymes

KW - Biocatalysis

KW - Regioselectivity

KW - Total turnover numbers

KW - Fenamic acid NSAIDs

KW - Drug metabolites

U2 - 10.1016/j.bmc.2014.06.022

DO - 10.1016/j.bmc.2014.06.022

M3 - Article

SN - 0968-0896

VL - 22

SP - 5613

EP - 5620

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 20

ER -