Application of imidazole-based ionic liquids in microwave-assisted extraction of trans-resveratrol from Gnetum Gnemon L. seeds

Arif Arrahman, Andini Gahayati, Dewi Rizky, Satya Muslimah, Abdul Mun’Im*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: This study aimed to compare the efficiency of three imidazole-based ionic liquids (ILs) in the microwave-assisted extraction (MAE) of trans-resveratrol from Gnetum gnemon seeds. Methods: Trans-resveratrol was quantitatively extracted using 1-hexyl-3-methylimidazolium bromide ([hmim]Br), 1-butyl-3-methylimidazolium chloride ([bmim]Cl), and 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) in a microwave oven. Extraction parameters, including solvent concentration, liquid-solid ratio, and extraction time, were optimized using response surface methodology on the basis of the Box-Behnken design. A reverse-phase high-performance liquid chromatography method was used to determine resveratrol content with acetonitrile: water (75:25 v/v) as the mobile phase. The total phenolic content was determined by the Folin-Ciocalteu method. Results: Under optimal conditions, the resveratrol content when extraction was performed using [hmim]Br, [bmim]Cl, and [bmim]BF4 was 0.068, 0.059, and 0.038 mg/g dry weight, respectively, and total phenolic content was 0.647, 1.736, and 1.436 mg gallic acid equivalent/g, respectively.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018
Externally publishedYes

Funding

The authors acknowledge the Directorate of Research and Humanity Engagement, Universitas Indonesia, for financial support through grant “Hibah PITTA 2017.” The authors also thank Prof. Dr. Ibrahim Jantan, M.Sc. of Universiti Kebangsaan, Malaysia, for supervising the work and editing this article.

FundersFunder number
Directorate of Research and Humanity Engagement
Universitas Indonesia

    Keywords

    • Gnetum gnemon L.
    • Ionic liquid
    • Melinjo
    • Microwave-assisted extraction
    • Response surface methodology
    • Resveratrol

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