Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy

L.A. Pardo, D Gómez-Varela, F Major, K. Sansuk, R. Leurs, B.R Downie, L.F. Tietze, W Stühmer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

KV10.1 has recently become generally accepted as a promising cancer target, as it is ectopically expressed in the majority of solid tumors. Due to its cell-surface accessibility, KV10.1 has a strong potential for tumor treatment and diagnosis. Given that its mode of action is likely independent of conventional cancer pathways such as tyrosine kinases, KV10.1 opens a novel window for treating cancer. In this review we will give an overview of the current status of data linking KV10.1 to cancer, and propose techniques that could exploit KV10.1's properties for the management of cancer. © 2012 Bentham Science Publishers.
Original languageEnglish
Pages (from-to)675-682
JournalCurrent Medicinal Chemistry
Volume19
Issue number5
DOIs
Publication statusPublished - 2012

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