Are Extremely Low Gestational Age Newborns Born to Obese Women at Increased Risk of Cerebral Palsy at 2 Years?

Jelske W. van der Burg*, T. Michael O’Shea, Karl Kuban, Elizabeth N. Allred, Nigel Paneth, Olaf Dammann, Alan Leviton

*Corresponding author for this work

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    The authors hypothesized that the risk of cerebral palsy at 2 years in children born extremely preterm to overweight and obese women is increased relative to the risk among children born to neither overweight nor obese women. In a multicenter prospective cohort study, the authors created multinomial logistic regression models of the risk of diparetic, quadriparetic, and hemiparetic cerebral palsy that included the prepregnancy body mass index of mothers of 1014 children born extremely preterm, cerebral palsy diagnoses of children at 2 years, as well as information about potential confounders. Overweight and obese women were not at increased risk of giving birth to a child who had cerebral palsy. The risk ratios associated with overweight varied between 1.1 for quadriparesis (95% CI = 0.5, 2.1) to 2.0 for hemiparesis (95% CI = 0.4, 9.8). The risk ratios associated with obesity varied between 0.7 for diparesis (95% CI = 0.2, 2.5) to 2.5 for hemiparesis (95% CI = 0.4, 13).

    Original languageEnglish
    Pages (from-to)216-224
    Number of pages9
    JournalJournal of Child Neurology
    Volume33
    Issue number3
    Early online date11 Jan 2018
    DOIs
    Publication statusPublished - Mar 2018

    Funding

    The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the National Institute of Neurological Disorders and Stroke (5U01NS040069-05; 2R01NS040069-06A2), the National Eye Institute (1-R01-EY021820-01A1), the NIH Office of the Director (1G3OD023348-01), and the National Institute of Child Health and Human Development (5P30HD018655-34).

    FundersFunder number
    NIH Office of the Director1G3OD023348-01
    National Eye InstituteR01EY021820
    National Institute of Neurological Disorders and Stroke5U01NS040069-05
    National Institute of Child Health and Human Development5P30HD018655-34

      Keywords

      • cerebral palsy
      • developmental disability
      • infant
      • outcome
      • preterm

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