Are skin senescence and immunosenescence linked within individuals?

Mariëtte E.C. Waaijer, David Goldeck, David A. Gunn, Diana van Heemst, Rudi G.J. Westendorp, Graham Pawelec, Andrea B. Maier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

With advancing age, many organs exhibit functional deterioration. The age-associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independently in each organ system or whether their prevalence within an individual reflects that individual's intrinsic aging process. To address this question, we studied senescence in two different organ systems in humans, namely skin and T cells in 80 middle-aged and older individuals from the Leiden Longevity Study. Epidermal p16INK4a positivity was associated with neither CD4+ nor CD8+ T-cell immunosenescence phenotype composites (i.e., end-stage differentiated/senescent T cells, including CD45RA+ CCR7- CD28- CD27- CD57+ KLRG1+ T cells). Dermal p16INK4a positivity was significantly associated with the CD4+ , but not with the CD8+ immunosenescence composite. We therefore conclude that there is limited evidence for a link between skin senescence and immunosenescence within individuals.

Original languageEnglish
Article numbere12956
Pages (from-to)1-5
Number of pages5
JournalAging Cell
Volume18
Issue number4
Early online date6 May 2019
DOIs
Publication statusPublished - Aug 2019

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T-Lymphocytes
Skin
Phenotype
Immunosenescence

Bibliographical note

© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Keywords

  • cellular senescence
  • human
  • immunosenescence
  • skin aging

Cite this

Waaijer, M. E. C., Goldeck, D., Gunn, D. A., van Heemst, D., Westendorp, R. G. J., Pawelec, G., & Maier, A. B. (2019). Are skin senescence and immunosenescence linked within individuals? Aging Cell, 18(4), 1-5. [e12956]. https://doi.org/10.1111/acel.12956
Waaijer, Mariëtte E.C. ; Goldeck, David ; Gunn, David A. ; van Heemst, Diana ; Westendorp, Rudi G.J. ; Pawelec, Graham ; Maier, Andrea B. / Are skin senescence and immunosenescence linked within individuals?. In: Aging Cell. 2019 ; Vol. 18, No. 4. pp. 1-5.
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Waaijer, MEC, Goldeck, D, Gunn, DA, van Heemst, D, Westendorp, RGJ, Pawelec, G & Maier, AB 2019, 'Are skin senescence and immunosenescence linked within individuals?' Aging Cell, vol. 18, no. 4, e12956, pp. 1-5. https://doi.org/10.1111/acel.12956

Are skin senescence and immunosenescence linked within individuals? / Waaijer, Mariëtte E.C.; Goldeck, David; Gunn, David A.; van Heemst, Diana; Westendorp, Rudi G.J.; Pawelec, Graham; Maier, Andrea B.

In: Aging Cell, Vol. 18, No. 4, e12956, 08.2019, p. 1-5.

Research output: Contribution to JournalArticleAcademicpeer-review

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Waaijer MEC, Goldeck D, Gunn DA, van Heemst D, Westendorp RGJ, Pawelec G et al. Are skin senescence and immunosenescence linked within individuals? Aging Cell. 2019 Aug;18(4):1-5. e12956. https://doi.org/10.1111/acel.12956