Arterial stiffness and Vitamin D levels: the Baltimore Longitudinal Study of Aging

F. Giallauria, Y. Milaneschi, T. Tanaka, M. Maggio, M. Canepa, P. Elango, C. Vigorito, E.G. Lakatta, L. Ferrucci, J. Strait

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    Abstract

    Context: The importance of vitamin D for bone health has long been acknowledged. Recent evidence suggests that vitamin D can also play a role in reducing the risk of several other diseases, including cardiovascular disease. Objective: The aim of this study is to test the hypothesis that 25-hydroxyvitamin D (25-OH D) is an independent cross-sectional correlate of central arterial stiffness in a normative aging study population. Design and Settings: We conducted a cross-sectional analysis. Subjects: We studied 1228 healthy volunteers (50% males; age, 70 ± 12 yr) of the Baltimore Longitudinal Study of Aging. Main Outcome Measures: We measured carotid-femoral pulse wave velocity (PWV) and 25-OH D levels. Results: We found a significant inverse association between PWV and 25-OH D levels (adjusted r
    Original languageEnglish
    Pages (from-to)3717-3723
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume97
    Issue number10
    DOIs
    Publication statusPublished - 2012

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