Artifact rates for 2D retinal nerve fiber layer thickness versus 3D retinal nerve fiber layer volume

Stephanie Choi; Firas Jassim; Edem Tsikata; Ziad Khoueir; Linda Y. Poon; Boy Braaf; Benjamin J. Vakoc; Brett E. Bouma; Johannes F. de Boer; Teresa C. Chen

doi:10.1167/tvst.9.3.12

Artifact rates for 2D retinal nerve fiber layer thickness versus 3D retinal nerve fiber layer volume

Stephanie Choi, Firas Jassim, Edem Tsikata, Ziad Khoueir, Linda Y. Poon, Boy Braaf, Benjamin J. Vakoc, Brett E. Bouma, Johannes F. de Boer, Teresa C. Chen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose: To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT)

Methods: Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for the 2.5–3.5-mm annulus. 3D RNFL measurements were calculated twice, once before and again after deletion of B-scans with artifacts and subsequent automated interpolation.

Results: For 2D scans, artifacts were present in 58.5% of B-scans (62 of 106) in glaucomatous eyes. For 3D scans, a mean of 35.4% of B-scans (34.3 of 97 B-scans per volume scan) contained an artifact in 106 glaucomatous eyes. For 3D data of glaucoma patients, mean global RNFL thickness values were similar before and after interpolation (77.0 ± 11.6 µm vs. 75.1 ± 11.2 µm, respectively; P = 0.23). Fewer clinically significant artifacts were noted in 3D RNFL scans, where only 7.5% of glaucomatous eyes (8 of 106) and 0% of normal eyes (0 of 95) had artifacts, compared to 2D RNFL scans, where 58.5% of glaucomatous eyes (62 of 106) and 14.7% of normal eyes (14 of 95) had artifacts.

Conclusions: Compared to 2D RNFL scans, 3D RNFL volume scans less often require manual correction to obtain accurate measurements.

Translational Relevance: 3D RNFL volume scans have fewer clinically significant artifacts compared to 2D RNFL thickness scans.

Original language	English
Article number	12
Pages (from-to)	1-10
Number of pages	10
Journal	TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
Volume	9
Issue number	3
Early online date	12 Feb 2020
DOIs	https://doi.org/10.1167/tvst.9.3.12
Publication status	Published - Feb 2020

Funding

Supported by grant number P41EB015903 from the Center for Biomedical OCT Research and Translation, awarded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (BB, BJV, and BEB). Also supported (TCC) by the National Institutes of Health award number UL1 RR 025758, Massachusetts Lions Eye Research Fund, American Glaucoma Society Mid-Career Award, Fidelity Charitable Fund, and Department of Defense Small Business Innovation Research, DHP15-016. The funding organizations had no role in the design or conduct of this research.

Funders	Funder number
Fidelity Charitable Fund	DHP15-016
National Institutes of Health	UL1 RR 025758
National Institute of Biomedical Imaging and Bioengineering
Massachusetts Lions Eye Research Fund
American Glaucoma Society

Keywords

Glaucoma
Optical coherence tomography
RNFL artifacts

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@article{ac268e1d0979450d8fb7d2fa8aabbfd9,

title = "Artifact rates for 2D retinal nerve fiber layer thickness versus 3D retinal nerve fiber layer volume",

abstract = " Purpose: To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT)Methods: Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for the 2.5–3.5-mm annulus. 3D RNFL measurements were calculated twice, once before and again after deletion of B-scans with artifacts and subsequent automated interpolation.Results: For 2D scans, artifacts were present in 58.5% of B-scans (62 of 106) in glaucomatous eyes. For 3D scans, a mean of 35.4% of B-scans (34.3 of 97 B-scans per volume scan) contained an artifact in 106 glaucomatous eyes. For 3D data of glaucoma patients, mean global RNFL thickness values were similar before and after interpolation (77.0 ± 11.6 µm vs. 75.1 ± 11.2 µm, respectively; P = 0.23). Fewer clinically significant artifacts were noted in 3D RNFL scans, where only 7.5% of glaucomatous eyes (8 of 106) and 0% of normal eyes (0 of 95) had artifacts, compared to 2D RNFL scans, where 58.5% of glaucomatous eyes (62 of 106) and 14.7% of normal eyes (14 of 95) had artifacts.Conclusions: Compared to 2D RNFL scans, 3D RNFL volume scans less often require manual correction to obtain accurate measurements.Translational Relevance: 3D RNFL volume scans have fewer clinically significant artifacts compared to 2D RNFL thickness scans. ",

keywords = "Glaucoma, Optical coherence tomography, RNFL artifacts",

author = "Stephanie Choi and Firas Jassim and Edem Tsikata and Ziad Khoueir and Poon, {Linda Y.} and Boy Braaf and Vakoc, {Benjamin J.} and Bouma, {Brett E.} and {de Boer}, {Johannes F.} and Chen, {Teresa C.}",

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T1 - Artifact rates for 2D retinal nerve fiber layer thickness versus 3D retinal nerve fiber layer volume

AU - Choi, Stephanie

AU - Jassim, Firas

AU - Tsikata, Edem

AU - Khoueir, Ziad

AU - Poon, Linda Y.

AU - Braaf, Boy

AU - Vakoc, Benjamin J.

AU - Bouma, Brett E.

AU - de Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2020/2

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N2 - Purpose: To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT)Methods: Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for the 2.5–3.5-mm annulus. 3D RNFL measurements were calculated twice, once before and again after deletion of B-scans with artifacts and subsequent automated interpolation.Results: For 2D scans, artifacts were present in 58.5% of B-scans (62 of 106) in glaucomatous eyes. For 3D scans, a mean of 35.4% of B-scans (34.3 of 97 B-scans per volume scan) contained an artifact in 106 glaucomatous eyes. For 3D data of glaucoma patients, mean global RNFL thickness values were similar before and after interpolation (77.0 ± 11.6 µm vs. 75.1 ± 11.2 µm, respectively; P = 0.23). Fewer clinically significant artifacts were noted in 3D RNFL scans, where only 7.5% of glaucomatous eyes (8 of 106) and 0% of normal eyes (0 of 95) had artifacts, compared to 2D RNFL scans, where 58.5% of glaucomatous eyes (62 of 106) and 14.7% of normal eyes (14 of 95) had artifacts.Conclusions: Compared to 2D RNFL scans, 3D RNFL volume scans less often require manual correction to obtain accurate measurements.Translational Relevance: 3D RNFL volume scans have fewer clinically significant artifacts compared to 2D RNFL thickness scans.

AB - Purpose: To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT)Methods: Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for the 2.5–3.5-mm annulus. 3D RNFL measurements were calculated twice, once before and again after deletion of B-scans with artifacts and subsequent automated interpolation.Results: For 2D scans, artifacts were present in 58.5% of B-scans (62 of 106) in glaucomatous eyes. For 3D scans, a mean of 35.4% of B-scans (34.3 of 97 B-scans per volume scan) contained an artifact in 106 glaucomatous eyes. For 3D data of glaucoma patients, mean global RNFL thickness values were similar before and after interpolation (77.0 ± 11.6 µm vs. 75.1 ± 11.2 µm, respectively; P = 0.23). Fewer clinically significant artifacts were noted in 3D RNFL scans, where only 7.5% of glaucomatous eyes (8 of 106) and 0% of normal eyes (0 of 95) had artifacts, compared to 2D RNFL scans, where 58.5% of glaucomatous eyes (62 of 106) and 14.7% of normal eyes (14 of 95) had artifacts.Conclusions: Compared to 2D RNFL scans, 3D RNFL volume scans less often require manual correction to obtain accurate measurements.Translational Relevance: 3D RNFL volume scans have fewer clinically significant artifacts compared to 2D RNFL thickness scans.

KW - Glaucoma

KW - Optical coherence tomography

KW - RNFL artifacts

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Artifact rates for 2D retinal nerve fiber layer thickness versus 3D retinal nerve fiber layer volume

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