Artificial metalloenzymes for asymmetric catalysis by creation of novel active sites in protein and DNA scaffolds

Ivana Drienovská, Gerard Roelfes*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Artificial metalloenzymes have emerged as a promising new approach to asymmetric catalysis. In our group, we are exploring novel artificial metalloenzyme designs involving creation of a new active site in a protein or DNA scaffold that does not have an existing binding pocket. In this review, we give an overview of the developments in the two approaches to artificial metalloenzymes for asymmetric catalysis investigated in our group: creation of a novel active site on a peptide or protein dimer interface and using DNA as a scaffold for artificial metalloenzymes.

Original languageEnglish
Pages (from-to)21-31
Number of pages11
JournalIsrael Journal of Chemistry
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 2015
Externally publishedYes

Keywords

  • asymmetric catalysis
  • biocatalysis
  • DNA
  • metalloenzymes
  • metalloproteins

Fingerprint Dive into the research topics of 'Artificial metalloenzymes for asymmetric catalysis by creation of novel active sites in protein and DNA scaffolds'. Together they form a unique fingerprint.

Cite this