Abstract
© 2021 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles.
Original language | English |
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Pages (from-to) | 2322-2333 |
Journal | Journal of Biomedical Materials Research. Part A |
Volume | 109 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1 Nov 2021 |
Funding
We thank Dr. Maria Grazia D'Elia for assistance on Western blotting and TUNEL assay experiments. We would also like to thank the ESA-ESTEC TEC-MMG LIS Lab, especially Mr. Alan Dowson for his support in preparation and during this study. This work has received funding from the European Space Agency (ESA) through the grant number CORA-GBF-2017-001. This work has received funding from the European Space Agency (ESA) through the grant number CORA‐GBF‐2017‐001.
Funders | Funder number |
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ESA-ESTEC | |
European Space Agency | CORA‐GBF‐2017‐001 |