Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect

A. Salvetti, A. Degl'Innocenti, G. Gambino, J.J.W.A. van Loon, C. Ippolito, S. Ghelardoni, E. Ghigo, L. Leoncino, M. Prato, L. Rossi, G. Ciofani

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

© 2021 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles.
Original languageEnglish
Pages (from-to)2322-2333
JournalJournal of Biomedical Materials Research - Part A
Volume109
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021

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