Abstract
A simple gas chromatographic assay of the psycho-stimulant pemoline in human urine, plasma and saliva has been developed. Instead of direct extraction of the drug from urine, plasma and saliva, it is hydrolyzed to 5-phenyl-2,4-oxazolidine-dione with 1 N hydrochloric acid. After extraction this compound is methylated with diazomethane and determined by gas-liquid chromatography using a capillary SCOT column with a mixed stationary phase, a solid injection system and a nitrogen-selective detector. 5-Phenyl-2,4-oxazolidinedione, which was also found to be a metabolite of pemoline, could be determined quantitatively in human urine.
| Original language | English |
|---|---|
| Pages (from-to) | 133-40 |
| Number of pages | 8 |
| Journal | Journal of Chromatography A |
| Volume | 157 |
| DOIs | |
| Publication status | Published - 21 Sept 1978 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 6 Clean Water and Sanitation
Keywords
- Chromatography, Gas
- Humans
- Nitrogen
- Pemoline
- Saliva
- Journal Article
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