TY - JOUR
T1 - Assessing aversive emotional states through the heart in mice: implications for cardiovascular dysregulation in affective disorders
AU - Stiedl, O.
AU - Jansen, R.F.
AU - Pieneman, A.W.
AU - Ogren, S.O.
AU - Meyer, M.
PY - 2009
Y1 - 2009
N2 - Beat-to-beat fluctuations of heart rate (HR) convey information of the brain state with the cardiac time series reflecting the flow of efferent nerve traffic of the autonomic nervous system. Instantaneous HR was studied in mice during exposure to novelty and the expression of fear conditioned to an auditory cue as affective challenge to characterize baseline dynamics and conditioned adjustments to learned fear. These studies included pharmacological and genetic interventions of brain systems implicated in aversive emotional states, the corticotropin-releasing factor (CRF) system and the serotonin (5-HT)
AB - Beat-to-beat fluctuations of heart rate (HR) convey information of the brain state with the cardiac time series reflecting the flow of efferent nerve traffic of the autonomic nervous system. Instantaneous HR was studied in mice during exposure to novelty and the expression of fear conditioned to an auditory cue as affective challenge to characterize baseline dynamics and conditioned adjustments to learned fear. These studies included pharmacological and genetic interventions of brain systems implicated in aversive emotional states, the corticotropin-releasing factor (CRF) system and the serotonin (5-HT)
UR - https://www.scopus.com/pages/publications/56949086529
UR - https://www.scopus.com/inward/citedby.url?scp=56949086529&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2008.08.015
DO - 10.1016/j.neubiorev.2008.08.015
M3 - Article
SN - 0149-7634
VL - 33
SP - 181
EP - 190
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 2
ER -
