Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans

K.S. Cover, R.A. van Schijndel, B.W. van Dijk, A. Redolfi, D.L. Knol, G. B. Frisoni, F. Barkhof, H. Vrenken

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    SienaX and Siena are widely used and fully automated algorithms for measuring whole brain volume and volume change in cross-sectional and longitudinal MRI studies and are particularly useful in studies of brain atrophy. The reproducibility of the algorithms was assessed using the 3D T1 weighted MP-RAGE scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. The back-to-back (BTB) MP-RAGE scans in the ADNI data set makes it a valuable benchmark against which to assess the performance of algorithms of measuring atrophy in the human brain with MRI scans. A total of 671 subjects were included for SienaX and 385 subjects for Siena. The annual percentage brain volume change (PBVC) rates were -0.65 ± 0.82%/year for the healthy controls, -1.15 ± 1.21%/year for mild cognitively impairment (MCI) and -1.84 ± 1.33%/year for AD, in line with previous findings. The median of the absolute value of the reproducibility of SienaX's normalized brain volume (NBV) was 0.96% while the 90th percentile was 5.11%. The reproducibility of Siena's PBVC had a median of 0.35% and a 90th percentile of 1.37%. While the median reproducibility for SienaX's NBV was in line with the values previously reported in the literature, the median reproducibility of Siena's PBVC was about twice that reported. Also, the 90th percentiles for both SienaX and Siena were about twice the size that would be expected for a Gaussian distribution. Because of the natural variation of the disease among patients over a year, a perfectly reproducible whole brain atrophy algorithm would reduce the estimated group size needed to detect a specified treatment effect by only 30% to 40% as compared to Siena's. © 2011 Elsevier Ireland Ltd.
    Original languageEnglish
    Pages (from-to)182-190
    JournalPsychiatry Research: Neuroimaging
    Volume193
    Issue number3
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Neuroimaging
    Atrophy
    Alzheimer Disease
    Magnetic Resonance Imaging
    Brain
    Benchmarking
    Normal Distribution
    Ireland
    Longitudinal Studies

    Cite this

    Cover, K. S., van Schijndel, R. A., van Dijk, B. W., Redolfi, A., Knol, D. L., Frisoni, G. B., ... Vrenken, H. (2011). Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans. Psychiatry Research: Neuroimaging, 193(3), 182-190. https://doi.org/10.1016/j.pscychresns.2011.02.012
    Cover, K.S. ; van Schijndel, R.A. ; van Dijk, B.W. ; Redolfi, A. ; Knol, D.L. ; Frisoni, G. B. ; Barkhof, F. ; Vrenken, H. / Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans. In: Psychiatry Research: Neuroimaging. 2011 ; Vol. 193, No. 3. pp. 182-190.
    @article{dbe3298f84a5438595ff82496b530d0e,
    title = "Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans",
    abstract = "SienaX and Siena are widely used and fully automated algorithms for measuring whole brain volume and volume change in cross-sectional and longitudinal MRI studies and are particularly useful in studies of brain atrophy. The reproducibility of the algorithms was assessed using the 3D T1 weighted MP-RAGE scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. The back-to-back (BTB) MP-RAGE scans in the ADNI data set makes it a valuable benchmark against which to assess the performance of algorithms of measuring atrophy in the human brain with MRI scans. A total of 671 subjects were included for SienaX and 385 subjects for Siena. The annual percentage brain volume change (PBVC) rates were -0.65 ± 0.82{\%}/year for the healthy controls, -1.15 ± 1.21{\%}/year for mild cognitively impairment (MCI) and -1.84 ± 1.33{\%}/year for AD, in line with previous findings. The median of the absolute value of the reproducibility of SienaX's normalized brain volume (NBV) was 0.96{\%} while the 90th percentile was 5.11{\%}. The reproducibility of Siena's PBVC had a median of 0.35{\%} and a 90th percentile of 1.37{\%}. While the median reproducibility for SienaX's NBV was in line with the values previously reported in the literature, the median reproducibility of Siena's PBVC was about twice that reported. Also, the 90th percentiles for both SienaX and Siena were about twice the size that would be expected for a Gaussian distribution. Because of the natural variation of the disease among patients over a year, a perfectly reproducible whole brain atrophy algorithm would reduce the estimated group size needed to detect a specified treatment effect by only 30{\%} to 40{\%} as compared to Siena's. {\circledC} 2011 Elsevier Ireland Ltd.",
    author = "K.S. Cover and {van Schijndel}, R.A. and {van Dijk}, B.W. and A. Redolfi and D.L. Knol and Frisoni, {G. B.} and F. Barkhof and H. Vrenken",
    year = "2011",
    doi = "10.1016/j.pscychresns.2011.02.012",
    language = "English",
    volume = "193",
    pages = "182--190",
    journal = "Psychiatry Research: Neuroimaging",
    issn = "0925-4927",
    publisher = "Elsevier Ireland Ltd",
    number = "3",

    }

    Cover, KS, van Schijndel, RA, van Dijk, BW, Redolfi, A, Knol, DL, Frisoni, GB, Barkhof, F & Vrenken, H 2011, 'Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans' Psychiatry Research: Neuroimaging, vol. 193, no. 3, pp. 182-190. https://doi.org/10.1016/j.pscychresns.2011.02.012

    Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans. / Cover, K.S.; van Schijndel, R.A.; van Dijk, B.W.; Redolfi, A.; Knol, D.L.; Frisoni, G. B.; Barkhof, F.; Vrenken, H.

    In: Psychiatry Research: Neuroimaging, Vol. 193, No. 3, 2011, p. 182-190.

    Research output: Contribution to JournalArticleAcademicpeer-review

    TY - JOUR

    T1 - Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans

    AU - Cover, K.S.

    AU - van Schijndel, R.A.

    AU - van Dijk, B.W.

    AU - Redolfi, A.

    AU - Knol, D.L.

    AU - Frisoni, G. B.

    AU - Barkhof, F.

    AU - Vrenken, H.

    PY - 2011

    Y1 - 2011

    N2 - SienaX and Siena are widely used and fully automated algorithms for measuring whole brain volume and volume change in cross-sectional and longitudinal MRI studies and are particularly useful in studies of brain atrophy. The reproducibility of the algorithms was assessed using the 3D T1 weighted MP-RAGE scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. The back-to-back (BTB) MP-RAGE scans in the ADNI data set makes it a valuable benchmark against which to assess the performance of algorithms of measuring atrophy in the human brain with MRI scans. A total of 671 subjects were included for SienaX and 385 subjects for Siena. The annual percentage brain volume change (PBVC) rates were -0.65 ± 0.82%/year for the healthy controls, -1.15 ± 1.21%/year for mild cognitively impairment (MCI) and -1.84 ± 1.33%/year for AD, in line with previous findings. The median of the absolute value of the reproducibility of SienaX's normalized brain volume (NBV) was 0.96% while the 90th percentile was 5.11%. The reproducibility of Siena's PBVC had a median of 0.35% and a 90th percentile of 1.37%. While the median reproducibility for SienaX's NBV was in line with the values previously reported in the literature, the median reproducibility of Siena's PBVC was about twice that reported. Also, the 90th percentiles for both SienaX and Siena were about twice the size that would be expected for a Gaussian distribution. Because of the natural variation of the disease among patients over a year, a perfectly reproducible whole brain atrophy algorithm would reduce the estimated group size needed to detect a specified treatment effect by only 30% to 40% as compared to Siena's. © 2011 Elsevier Ireland Ltd.

    AB - SienaX and Siena are widely used and fully automated algorithms for measuring whole brain volume and volume change in cross-sectional and longitudinal MRI studies and are particularly useful in studies of brain atrophy. The reproducibility of the algorithms was assessed using the 3D T1 weighted MP-RAGE scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. The back-to-back (BTB) MP-RAGE scans in the ADNI data set makes it a valuable benchmark against which to assess the performance of algorithms of measuring atrophy in the human brain with MRI scans. A total of 671 subjects were included for SienaX and 385 subjects for Siena. The annual percentage brain volume change (PBVC) rates were -0.65 ± 0.82%/year for the healthy controls, -1.15 ± 1.21%/year for mild cognitively impairment (MCI) and -1.84 ± 1.33%/year for AD, in line with previous findings. The median of the absolute value of the reproducibility of SienaX's normalized brain volume (NBV) was 0.96% while the 90th percentile was 5.11%. The reproducibility of Siena's PBVC had a median of 0.35% and a 90th percentile of 1.37%. While the median reproducibility for SienaX's NBV was in line with the values previously reported in the literature, the median reproducibility of Siena's PBVC was about twice that reported. Also, the 90th percentiles for both SienaX and Siena were about twice the size that would be expected for a Gaussian distribution. Because of the natural variation of the disease among patients over a year, a perfectly reproducible whole brain atrophy algorithm would reduce the estimated group size needed to detect a specified treatment effect by only 30% to 40% as compared to Siena's. © 2011 Elsevier Ireland Ltd.

    U2 - 10.1016/j.pscychresns.2011.02.012

    DO - 10.1016/j.pscychresns.2011.02.012

    M3 - Article

    VL - 193

    SP - 182

    EP - 190

    JO - Psychiatry Research: Neuroimaging

    JF - Psychiatry Research: Neuroimaging

    SN - 0925-4927

    IS - 3

    ER -