Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT

Lihuan Guan; Cheng Hwee Soh; Esmee M. Reijnierse; Wen Kwang Lim; Andrea B. Maier

doi:10.1016/j.mad.2022.111648

Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT

Lihuan Guan
, Cheng Hwee Soh
, Esmee M. Reijnierse
, Wen Kwang Lim
, Andrea B. Maier

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based on laboratory tests (FILab). This study aimed to modify the FI-Lab (mFI-Lab) by accounting for the number of laboratory measurements and compare its validity to predict institutionalization and mortality at three-month post-discharge with the clinical frailty scale (CFS) in geriatric rehabilitation inpatients. In 1819 patients (median age 83.3 [77.6–88.3], 56.6% female), a higher FI-Lab was not associated with institutionalization but a higher risk of mortality. A higher mFI-Lab was associated with lower odds of institutionalization but a higher risk of mortality. A higher CFS was associated with institutionalization and higher mortality. The Akaike information criterion value was lowest for the CFS, followed by the mFI-Lab and the FI-Lab. The CFS is better than the mFI-Lab predicting short-term adverse outcomes in geriatric rehabilitation inpatients. When using laboratory data to estimate frailty, the mFI-Lab rather than the FI-Lab should be used.

Original language	English
Article number	111648
Journal	Mechanisms of Ageing and Development
Volume	203
DOIs	https://doi.org/10.1016/j.mad.2022.111648
Publication status	Published - 1 Apr 2022

Funding

All authors thank the multidisciplinary team members of the Royal Park Campus, the Royal Melbourne Hospital in their involvement in the RESORT study for their clinical work and the @AgeMelbourne team for their role in the data collection. The authors would also like to thank the Department of Pathology, the Royal Melbourne Hospital for assessing the pathology data. The study was funded by an unrestricted grant of the University of Melbourne, Australia and the Medical Research Future Fund by the Melbourne Academic Centre for Health, Australia. This work was supported by an unrestricted grant of the University of Melbourne received by Prof. Andrea B. Maier and the Medical Research Future Fund (MRFF) provided by the Melbourne Academic Centre for Health (MACH). Lihuan Guan has received a China Scholarship Council - University of Melbourne PhD Scholarship. This work was supported by an unrestricted grant of the University of Melbourne received by Prof. Andrea B. Maier and the Medical Research Future Fund (MRFF) provided by the Melbourne Academic Centre for Health (MACH). Lihuan Guan has received a China Scholarship Council - University of Melbourne PhD Scholarship.

Funders
Medical Research Future Fund
Melbourne Academic Centre for Health
Melbourne Academic Centre for Health, Australia
University of Melbourne
China Scholarship Council

Access to Document

10.1016/j.mad.2022.111648

Persistent URL (handle)

Persistent link

Cite this

@article{662cb1e954914e2fbac7455f5d3292fe,

title = "Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT",

abstract = "A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based on laboratory tests (FILab). This study aimed to modify the FI-Lab (mFI-Lab) by accounting for the number of laboratory measurements and compare its validity to predict institutionalization and mortality at three-month post-discharge with the clinical frailty scale (CFS) in geriatric rehabilitation inpatients. In 1819 patients (median age 83.3 [77.6–88.3], 56.6\% female), a higher FI-Lab was not associated with institutionalization but a higher risk of mortality. A higher mFI-Lab was associated with lower odds of institutionalization but a higher risk of mortality. A higher CFS was associated with institutionalization and higher mortality. The Akaike information criterion value was lowest for the CFS, followed by the mFI-Lab and the FI-Lab. The CFS is better than the mFI-Lab predicting short-term adverse outcomes in geriatric rehabilitation inpatients. When using laboratory data to estimate frailty, the mFI-Lab rather than the FI-Lab should be used.",

author = "Lihuan Guan and Soh, \{Cheng Hwee\} and Reijnierse, \{Esmee M.\} and Lim, \{Wen Kwang\} and Maier, \{Andrea B.\}",

year = "2022",

month = apr,

day = "1",

doi = "10.1016/j.mad.2022.111648",

language = "English",

volume = "203",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients

T2 - RESORT

AU - Guan, Lihuan

AU - Soh, Cheng Hwee

AU - Reijnierse, Esmee M.

AU - Lim, Wen Kwang

AU - Maier, Andrea B.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based on laboratory tests (FILab). This study aimed to modify the FI-Lab (mFI-Lab) by accounting for the number of laboratory measurements and compare its validity to predict institutionalization and mortality at three-month post-discharge with the clinical frailty scale (CFS) in geriatric rehabilitation inpatients. In 1819 patients (median age 83.3 [77.6–88.3], 56.6% female), a higher FI-Lab was not associated with institutionalization but a higher risk of mortality. A higher mFI-Lab was associated with lower odds of institutionalization but a higher risk of mortality. A higher CFS was associated with institutionalization and higher mortality. The Akaike information criterion value was lowest for the CFS, followed by the mFI-Lab and the FI-Lab. The CFS is better than the mFI-Lab predicting short-term adverse outcomes in geriatric rehabilitation inpatients. When using laboratory data to estimate frailty, the mFI-Lab rather than the FI-Lab should be used.

AB - A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based on laboratory tests (FILab). This study aimed to modify the FI-Lab (mFI-Lab) by accounting for the number of laboratory measurements and compare its validity to predict institutionalization and mortality at three-month post-discharge with the clinical frailty scale (CFS) in geriatric rehabilitation inpatients. In 1819 patients (median age 83.3 [77.6–88.3], 56.6% female), a higher FI-Lab was not associated with institutionalization but a higher risk of mortality. A higher mFI-Lab was associated with lower odds of institutionalization but a higher risk of mortality. A higher CFS was associated with institutionalization and higher mortality. The Akaike information criterion value was lowest for the CFS, followed by the mFI-Lab and the FI-Lab. The CFS is better than the mFI-Lab predicting short-term adverse outcomes in geriatric rehabilitation inpatients. When using laboratory data to estimate frailty, the mFI-Lab rather than the FI-Lab should be used.

UR - https://www.scopus.com/pages/publications/85125343953

UR - https://www.scopus.com/pages/publications/85125343953#tab=citedBy

U2 - 10.1016/j.mad.2022.111648

DO - 10.1016/j.mad.2022.111648

M3 - Article

SN - 0047-6374

VL - 203

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

M1 - 111648

ER -

Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT

Abstract

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this